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• W2886350075 abstract "Cardiovascular disease remains the largest single cause of mortality in the Western world, despite significant advances in clinical management over the years. Unfortunately, the development of new cardiovascular medicines is stagnating and can in part be attributed to the difficulty of screening for novel therapeutic strategies due to a lack of suitable models. The advent of human induced pluripotent stem cells and the ability to make limitless numbers of cardiomyocytes could revolutionize heart disease modeling and drug discovery. This review summarizes the state of the art in the field, describes the strengths and weaknesses of the technology, and applications where the model system would be most appropriate." @default.
• W2886350075 created "2018-08-22" @default.
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• W2886350075 date "2018-10-01" @default.
• W2886350075 modified "2023-10-12" @default.
• W2886350075 title "Will iPSC-cardiomyocytes revolutionize the discovery of drugs for heart disease?" @default.
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• W2886350075 doi "https://doi.org/10.1016/j.coph.2018.07.003" @default.
• W2886350075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6261432" @default.
• W2886350075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30081259" @default.
• W2886350075 hasPublicationYear "2018" @default.
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