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• W2886359666 startingPage "31432" @default.
• W2886359666 abstract "Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine skin cancer. In more than 80% of the cases, Merkel cell polyomavirus (MCPyV) is a causal factor. The oncogenic potential of MCPyV is mediated through its viral oncoproteins, large T antigen (LT) and small t antigen (sT). To investigate the role of cytokines in MCC, a PCR array analysis for genes encoding inflammatory cytokines and receptors was performed on MCPyV-negative and MCPyV-positive MCC cell lines, respectively. We detected an increased expression of CCL17/TARC in the MCPyV-positive MKL2 cell line compared to the MCPyV-negative MCC13 cell line. Transfection studies in MCC13 cells with LT expression plasmid, and a luciferase reporter plasmid containing the CCL17/TARC promoter, exhibited stimulated promoter activity. Interestingly, the ectopic expression of CCL17/TARC upregulated MCPyV early and late promoter activities in MCC13 cells. Furthermore, recombinant CCL17/TARC activated both the mitogen-activated protein kinase and the NF-κB pathways. Finally, immunohistochemical staining on human MCC tissues showed a strong staining of CCL17/TARC and its receptor CCR4 in both LT-positive and -negative MCC. Taken together, CCL17/TARC and CCR4 may be a potential target in MCC therapy providing MCC patients with a better overall survival outcome." @default.
• W2886359666 created "2018-08-22" @default.
• W2886359666 creator A5011176090 @default.
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• W2886359666 creator A5077483784 @default.
• W2886359666 creator A5082154362 @default.
• W2886359666 date "2018-07-31" @default.
• W2886359666 modified "2023-10-18" @default.
• W2886359666 title "CCL17/TARC and CCR4 expression in Merkel cell carcinoma" @default.
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• W2886359666 doi "https://doi.org/10.18632/oncotarget.25836" @default.
• W2886359666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6101144" @default.
• W2886359666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30140381" @default.
• W2886359666 hasPublicationYear "2018" @default.
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