Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886375655> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2886375655 abstract "Objective— Platelet activation occurs in response to adhesion receptors for von Willebrand factor (GPIb-V-IX) and collagen (GPVI and α2β1 integrin) acting upstream of phospholipase C (PLC) γ2. However, PLCβ transduces signals from Gαq protein-coupled receptors for soluble agonists (P2y1, TxA2/TP, and thrombin/PAR). A Gi-dependent pathway amplifies most of these responses. Methods and Results— To evaluate the role of adhesion receptors signaling in arterial thrombosis, PLCγ2 knockout mice were studied in blood perfusion assays over fibrillar collagen and in a laser-induced mesenteric artery model of thrombosis. In vitro, PLCγ2-deficient platelets formed a single layer incapable of generating a thrombus on collagen, whereas Gαq-deficient platelets formed reduced size aggregates compared with wild-type cells. In the in vivo model, PLCγ2−/− mice displayed defective thrombus formation in superficial lesions but productive thrombosis after a more severe laser injury. In contrast, resistance to thrombosis was ob..." @default.
- W2886375655 created "2018-08-22" @default.
- W2886375655 creator A5007107218 @default.
- W2886375655 creator A5027357763 @default.
- W2886375655 creator A5029055459 @default.
- W2886375655 creator A5030767695 @default.
- W2886375655 creator A5044438779 @default.
- W2886375655 creator A5050950608 @default.
- W2886375655 creator A5072178118 @default.
- W2886375655 date "2005-06-01" @default.
- W2886375655 modified "2023-09-26" @default.
- W2886375655 title "Importance of Platelet Phospholipase Cγ2 Signaling in Arterial Thrombosis as a Function of Lesion Severity" @default.
- W2886375655 hasPublicationYear "2005" @default.
- W2886375655 type Work @default.
- W2886375655 sameAs 2886375655 @default.
- W2886375655 citedByCount "0" @default.
- W2886375655 crossrefType "journal-article" @default.
- W2886375655 hasAuthorship W2886375655A5007107218 @default.
- W2886375655 hasAuthorship W2886375655A5027357763 @default.
- W2886375655 hasAuthorship W2886375655A5029055459 @default.
- W2886375655 hasAuthorship W2886375655A5030767695 @default.
- W2886375655 hasAuthorship W2886375655A5044438779 @default.
- W2886375655 hasAuthorship W2886375655A5050950608 @default.
- W2886375655 hasAuthorship W2886375655A5072178118 @default.
- W2886375655 hasConcept C126322002 @default.
- W2886375655 hasConcept C134018914 @default.
- W2886375655 hasConcept C170493617 @default.
- W2886375655 hasConcept C185592680 @default.
- W2886375655 hasConcept C195687474 @default.
- W2886375655 hasConcept C2778597717 @default.
- W2886375655 hasConcept C2779394231 @default.
- W2886375655 hasConcept C2780009322 @default.
- W2886375655 hasConcept C2780573682 @default.
- W2886375655 hasConcept C2780868729 @default.
- W2886375655 hasConcept C2781362458 @default.
- W2886375655 hasConcept C2993802102 @default.
- W2886375655 hasConcept C3018697912 @default.
- W2886375655 hasConcept C71924100 @default.
- W2886375655 hasConcept C86803240 @default.
- W2886375655 hasConcept C89560881 @default.
- W2886375655 hasConcept C95444343 @default.
- W2886375655 hasConceptScore W2886375655C126322002 @default.
- W2886375655 hasConceptScore W2886375655C134018914 @default.
- W2886375655 hasConceptScore W2886375655C170493617 @default.
- W2886375655 hasConceptScore W2886375655C185592680 @default.
- W2886375655 hasConceptScore W2886375655C195687474 @default.
- W2886375655 hasConceptScore W2886375655C2778597717 @default.
- W2886375655 hasConceptScore W2886375655C2779394231 @default.
- W2886375655 hasConceptScore W2886375655C2780009322 @default.
- W2886375655 hasConceptScore W2886375655C2780573682 @default.
- W2886375655 hasConceptScore W2886375655C2780868729 @default.
- W2886375655 hasConceptScore W2886375655C2781362458 @default.
- W2886375655 hasConceptScore W2886375655C2993802102 @default.
- W2886375655 hasConceptScore W2886375655C3018697912 @default.
- W2886375655 hasConceptScore W2886375655C71924100 @default.
- W2886375655 hasConceptScore W2886375655C86803240 @default.
- W2886375655 hasConceptScore W2886375655C89560881 @default.
- W2886375655 hasConceptScore W2886375655C95444343 @default.
- W2886375655 hasLocation W28863756551 @default.
- W2886375655 hasOpenAccess W2886375655 @default.
- W2886375655 hasPrimaryLocation W28863756551 @default.
- W2886375655 hasRelatedWork W1530702942 @default.
- W2886375655 hasRelatedWork W2008423937 @default.
- W2886375655 hasRelatedWork W2038326745 @default.
- W2886375655 hasRelatedWork W2046673583 @default.
- W2886375655 hasRelatedWork W2050695042 @default.
- W2886375655 hasRelatedWork W2063356644 @default.
- W2886375655 hasRelatedWork W2065167665 @default.
- W2886375655 hasRelatedWork W2070130998 @default.
- W2886375655 hasRelatedWork W2115671168 @default.
- W2886375655 hasRelatedWork W2119605677 @default.
- W2886375655 hasRelatedWork W2144095528 @default.
- W2886375655 hasRelatedWork W2149570553 @default.
- W2886375655 hasRelatedWork W2156269810 @default.
- W2886375655 hasRelatedWork W2162190435 @default.
- W2886375655 hasRelatedWork W2735213051 @default.
- W2886375655 hasRelatedWork W2738072667 @default.
- W2886375655 hasRelatedWork W2752383102 @default.
- W2886375655 hasRelatedWork W2901347999 @default.
- W2886375655 hasRelatedWork W2913707105 @default.
- W2886375655 hasRelatedWork W128070872 @default.
- W2886375655 isParatext "false" @default.
- W2886375655 isRetracted "false" @default.
- W2886375655 magId "2886375655" @default.
- W2886375655 workType "article" @default.