Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886378412> ?p ?o ?g. }
- W2886378412 endingPage "e0200677" @default.
- W2886378412 startingPage "e0200677" @default.
- W2886378412 abstract "Previous systematic reviews have reported positive associations between Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new primary studies, there is a need for a comprehensive systematic review. Our objectives were to investigate if MCs are associated with non-specific LBP and/or activity limitation and if such associations are modified by other factors.A protocol for this review was registered at PROSPERO prior to commencing the work (PROSPERO record: CRD42015017350). The MEDLINE, CINAHL and EMBASE databases were searched for relevant studies from first record to June 15th 2016. Prospective or retrospective cross-sectional cohort studies and case-control studies including people of all ages from general, working and clinical study populations were eligible for inclusion. Risk of bias assessment and data extraction for associations and potential modifiers were completed independently by pairs of reviewers. Meta-analysis was performed for homogeneous studies and presented as odds ratios (OR) with 95% CI.In all, 5210 citations were identified and 31 studies were included. One study had low risk of bias. Fifteen studies (48%) reported statistically significant positive associations between MCs and LBP and one study found a statistically significant negative association. Meta-analysis performed for studies using concordant pain with provocative discography as the clinical outcome resulted in an OR of 4.01 (1.52-10.61). One of seven studies reported a statistically significant positive association between MCs and activity limitation. Lumbar disc level and disc degeneration were found to modify the association between MCs and LBP.The results from this comprehensive systematic review indicate that the associations between MCs and LBP-related outcomes are inconsistent. The high risk of bias and the heterogeneity in terms of study samples, clinical outcomes and prevalence estimates of MCs and LBP may explain these findings. It is likely that new studies with low risk of bias will affect the direction and strength of these associations." @default.
- W2886378412 created "2018-08-22" @default.
- W2886378412 creator A5003369225 @default.
- W2886378412 creator A5009026317 @default.
- W2886378412 creator A5010406677 @default.
- W2886378412 creator A5010697918 @default.
- W2886378412 creator A5015308639 @default.
- W2886378412 creator A5017467065 @default.
- W2886378412 creator A5018269158 @default.
- W2886378412 creator A5024646488 @default.
- W2886378412 creator A5032813108 @default.
- W2886378412 creator A5074181836 @default.
- W2886378412 date "2018-08-01" @default.
- W2886378412 modified "2023-10-18" @default.
- W2886378412 title "Modic changes—Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis" @default.
- W2886378412 cites W119179058 @default.
- W2886378412 cites W1504138010 @default.
- W2886378412 cites W1509135903 @default.
- W2886378412 cites W181521395 @default.
- W2886378412 cites W1823763928 @default.
- W2886378412 cites W1880367091 @default.
- W2886378412 cites W1963843076 @default.
- W2886378412 cites W1963993024 @default.
- W2886378412 cites W1968105317 @default.
- W2886378412 cites W1968145476 @default.
- W2886378412 cites W1981419401 @default.
- W2886378412 cites W1984146536 @default.
- W2886378412 cites W1989558609 @default.
- W2886378412 cites W1989815215 @default.
- W2886378412 cites W1995838278 @default.
- W2886378412 cites W2002928056 @default.
- W2886378412 cites W2007452473 @default.
- W2886378412 cites W2007484908 @default.
- W2886378412 cites W2007529315 @default.
- W2886378412 cites W2009584532 @default.
- W2886378412 cites W2010504874 @default.
- W2886378412 cites W2012036655 @default.
- W2886378412 cites W2012289207 @default.
- W2886378412 cites W2017041097 @default.
- W2886378412 cites W2022235629 @default.
- W2886378412 cites W2023363479 @default.
- W2886378412 cites W2023557439 @default.
- W2886378412 cites W2030519596 @default.
- W2886378412 cites W2031842679 @default.
- W2886378412 cites W2033034723 @default.
- W2886378412 cites W2033568227 @default.
- W2886378412 cites W2036456452 @default.
- W2886378412 cites W2037380947 @default.
- W2886378412 cites W2040215497 @default.
- W2886378412 cites W2040529098 @default.
- W2886378412 cites W2043325704 @default.
- W2886378412 cites W2049469760 @default.
- W2886378412 cites W2051462223 @default.
- W2886378412 cites W2064671239 @default.
- W2886378412 cites W2067440183 @default.
- W2886378412 cites W2068665095 @default.
- W2886378412 cites W2075630003 @default.
- W2886378412 cites W2076135184 @default.
- W2886378412 cites W2076694010 @default.
- W2886378412 cites W2077503364 @default.
- W2886378412 cites W2077938363 @default.
- W2886378412 cites W2081629042 @default.
- W2886378412 cites W2084191142 @default.
- W2886378412 cites W2084202545 @default.
- W2886378412 cites W2086689094 @default.
- W2886378412 cites W2087485068 @default.
- W2886378412 cites W2089324539 @default.
- W2886378412 cites W2090881743 @default.
- W2886378412 cites W2092585554 @default.
- W2886378412 cites W2093469331 @default.
- W2886378412 cites W2097211054 @default.
- W2886378412 cites W2098082628 @default.
- W2886378412 cites W2099190626 @default.
- W2886378412 cites W2106372247 @default.
- W2886378412 cites W2107638293 @default.
- W2886378412 cites W2114602226 @default.
- W2886378412 cites W2115872708 @default.
- W2886378412 cites W2120170097 @default.
- W2886378412 cites W2141302405 @default.
- W2886378412 cites W2147817944 @default.
- W2886378412 cites W2156987533 @default.
- W2886378412 cites W2157129792 @default.
- W2886378412 cites W2157570481 @default.
- W2886378412 cites W2185657988 @default.
- W2886378412 cites W2196316634 @default.
- W2886378412 cites W2203834106 @default.
- W2886378412 cites W2299746249 @default.
- W2886378412 cites W2315448502 @default.
- W2886378412 cites W2324199759 @default.
- W2886378412 cites W2331908715 @default.
- W2886378412 cites W2332311596 @default.
- W2886378412 cites W2332848001 @default.
- W2886378412 cites W2333609153 @default.
- W2886378412 cites W2414944225 @default.
- W2886378412 cites W2472663952 @default.
- W2886378412 cites W2992332983 @default.
- W2886378412 cites W2998494162 @default.
- W2886378412 doi "https://doi.org/10.1371/journal.pone.0200677" @default.