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• W2886385135 abstract "The present study was to develop a stable and sustained-release delivery system of tacrolimus (TCM). TCM is a macrolide antibiotic used as an immunosuppressant. It is formulated as a microsponge, which is a safe and effective delivery system with reduced side effects.The method used to prepare ethyl cellulose (EC) and xanthan gum (XG)-facilitated EC-based microsponges employed emulsification and modified double emulsification techniques. TCM-containing microsponges were prepared using varying concentrations followed by evaluation of micromeritics, compatibility of drug and excipients, production yield, drug content and entrapment efficiency, zeta potential, size distribution and drug release.The results showed excellent flow properties with adequate entrapment efficiency of the system and satisfactory release of active pharmaceutical ingredient. In vitro dissolution studies, which were conducted to determine the amount of drug released, illustrated a pronounced sustained effect up to 8 h. Zeta size and zeta potential analysis of microsponges confirmed the existence of micro-sized (1.99-3.09 µm) and stable particles (-15.33 to -3.38 mV), respectively.Conclusively, the applied technique and selected combination of ingredients were found suitable for the preparation of TCM-containing sustained-release microsponges." @default.
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• W2886385135 date "2018-08-01" @default.
• W2886385135 modified "2023-09-27" @default.
• W2886385135 title "Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges" @default.
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• W2886385135 doi "https://doi.org/10.2147/ijn.s166413" @default.
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