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• W2886387389 abstract "Abstract Organismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo , and the mechanisms by which noise is filtered during development are largely unknown. To identify the noise-canceling mechanism, we used the fly visual system, in which the timing of differentiation of neural stem cells is spatio-temporally ordered. Our mathematical model predicts that JAK/STAT signaling contributes to noise canceling to guarantee the robust progression of the differentiation wave in silico . We further demonstrate that the suppression of JAK/STAT signaling causes stochastic and ectopic neural stem cell differentiation in vivo , suggesting an evolutionarily conserved function of JAK/STAT to regulate the robustness of stem cell differentiation." @default.
• W2886387389 created "2018-08-22" @default.
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• W2886387389 date "2018-08-20" @default.
• W2886387389 modified "2023-10-17" @default.
• W2886387389 title "JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise" @default.
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• W2886387389 doi "https://doi.org/10.1038/s41598-018-30929-1" @default.
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