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- W2886414046 abstract "In this issue of Hospital Pediatrics , Young et al1 present more evidence that a positive urinalysis result alone is not associated with a higher prevalence of bacterial meningitis in febrile infants 29 to 60 days of age. In this retrospective cohort study, 835 febrile infants underwent a full “sepsis workup,” including cerebrospinal fluid (CSF) testing, and the prevalence of bacterial meningitis was equivalent among infants with a positive versus a negative urinalysis (0.9% vs 1.0%, respectively). Furthermore, the authors separately analyzed 345 febrile infants 29 to 60 days of age with a positive urinalysis who were treated with antibiotics without CSF testing. None of these infants were subsequently diagnosed with bacterial meningitis or experienced an adverse outcome within 1 month.1To date, all of the criteria developed and commonly used for the risk stratification of febrile infants (Rochester, Philadelphia, Boston, Step-by-Step approach) include a positive urinalysis result as a parameter that classifies an infant as “not low-risk” for an invasive bacterial infection (ie, bacteremia and/or bacterial meningitis).2–6 On 1 hand, this classification makes sense because the prevalence of bacteremia among infants with a positive urinalysis is ∼6% to 9%,7–9 and these infants are theoretically at an increased risk for seeding the meninges leading to meningitis. However, with their data, Young et al1 contradict this logic by showing that infants with a positive urinalysis are at no greater risk of meningitis than other febrile …" @default.
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- W2886414046 date "2018-08-01" @default.
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- W2886414046 title "Is It Time to Stop Classifying Febrile Infants With Positive Urinalyses as High-Risk for Meningitis?" @default.
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- W2886414046 doi "https://doi.org/10.1542/hpeds.2018-0064" @default.
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