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- W2886416511 abstract "Voltage-sensing phosphatase (VSP) contains a voltage sensor domain (VSD) similar to that in voltage-gated ion channels, and a phosphoinositide phosphatase region similar to phosphatase and tensin homolog deleted on chromosome 10 (PTEN). The VSP gene is conserved from unicellular organisms to higher vertebrates. Membrane depolarization induces electrical driven conformational rearrangement in the VSD, which is translated into catalytic enzyme activity. Biophysical and structural characterization has revealed details of the mechanisms underlying the molecular functions of VSP. Coupling between the VSD and the enzyme is tight, such that enzyme activity is tuned in a graded fashion to the membrane voltage. Upon VSP activation, multiple species of phosphoinositides are simultaneously altered, and the profile of enzyme activity depends on the history of the membrane potential. VSPs have been the obvious candidate link between membrane potential and phosphoinositide regulation. However, patterns of voltage change regulating VSP in native cells remain largely unknown. This review addresses the current understanding of the biophysical biochemical properties of VSP and provides new insight into the proposed functions of VSP." @default.
- W2886416511 created "2018-08-22" @default.
- W2886416511 creator A5006763756 @default.
- W2886416511 creator A5041231691 @default.
- W2886416511 creator A5057595184 @default.
- W2886416511 date "2018-10-01" @default.
- W2886416511 modified "2023-10-14" @default.
- W2886416511 title "Voltage-Sensing Phosphatases: Biophysics, Physiology, and Molecular Engineering" @default.
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