FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886447721> ?p ?o ?g. }

• W2886447721 abstract "Mast cell and testosterone interactions involved in renal fibrosis in rats subjected to unilateral ureteral obstruction (UUO) were investigated. Orchiectomized (ORX) and nonorchiectomized Wistar rats were subjected to UUO, and a nonorchiectomized group was sham-operated (control: SO). Animals from the UUO group were treated with saline or sodium cromoglycate (CG). Some ORX rats from the saline or CG groups also received testosterone propionate replacement (TR). Kidneys and blood were collected 14 d after UUO or SO. Kidney sections were stained with toluidine blue to quantify mast cells, and picrosirius red was used for collagen analysis. Immunohistochemistry for α-smooth muscle actin (α-SMA) and proliferating cell nuclear antigen (PCNA) expression was also performed. Plasma testosterone levels (PTLs) were measured. ORX decreased and TR normalized PTLs. UUO increased mast cell density in the kidney pelvis, but not in the kidney parenchyma. UUO increased mast cell degranulation, and CG or ORX inhibited this effect. TR partially reversed the effect of ORX on mast cell degranulation, and CG partially inhibited that effect of TR. UUO increased the collagen areas of the renal parenchyma, whereas CG or ORX abolished that alteration; TR reversed the effects of ORX, and CG partially inhibited that effect of TR. UUO increased tubulointerstitial α-SMA expression and PCNA-positive cells, and these changes were sensitive to ORX or CG to the same degree, while TR again reversed the effect of ORX. Renal fibrosis after UUO appears to be determined by interactions between testosterone and mast cells." @default.
• W2886447721 created "2018-08-22" @default.
• W2886447721 creator A5020539547 @default.
• W2886447721 creator A5024636855 @default.
• W2886447721 creator A5037335521 @default.
• W2886447721 creator A5053651303 @default.
• W2886447721 creator A5064894678 @default.
• W2886447721 creator A5067860180 @default.
• W2886447721 creator A5071093272 @default.
• W2886447721 creator A5071389745 @default.
• W2886447721 creator A5087090947 @default.
• W2886447721 date "2018-08-01" @default.
• W2886447721 modified "2023-09-27" @default.
• W2886447721 title "Testosterone and Mast Cell Interactions in the Development of Kidney Fibrosis after Unilateral Ureteral Obstruction in Rats" @default.
• W2886447721 cites W1970853396 @default.
• W2886447721 cites W1981980541 @default.
• W2886447721 cites W1983846424 @default.
• W2886447721 cites W1987171689 @default.
• W2886447721 cites W1990036288 @default.
• W2886447721 cites W1995129870 @default.
• W2886447721 cites W1997210759 @default.
• W2886447721 cites W2017527017 @default.
• W2886447721 cites W2019843557 @default.
• W2886447721 cites W2043695204 @default.
• W2886447721 cites W2054090757 @default.
• W2886447721 cites W2068512021 @default.
• W2886447721 cites W2078894098 @default.
• W2886447721 cites W2082391434 @default.
• W2886447721 cites W2082608089 @default.
• W2886447721 cites W2090072574 @default.
• W2886447721 cites W2098005084 @default.
• W2886447721 cites W2101766543 @default.
• W2886447721 cites W2114925869 @default.
• W2886447721 cites W2395801708 @default.
• W2886447721 cites W2611859458 @default.
• W2886447721 cites W3084496997 @default.
• W2886447721 doi "https://doi.org/10.1248/bpb.b17-00829" @default.
• W2886447721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30068865" @default.
• W2886447721 hasPublicationYear "2018" @default.
• W2886447721 type Work @default.
• W2886447721 sameAs 2886447721 @default.
• W2886447721 citedByCount "2" @default.
• W2886447721 countsByYear W28864477212019 @default.
• W2886447721 countsByYear W28864477212022 @default.
• W2886447721 crossrefType "journal-article" @default.
• W2886447721 hasAuthorship W2886447721A5020539547 @default.
• W2886447721 hasAuthorship W2886447721A5024636855 @default.
• W2886447721 hasAuthorship W2886447721A5037335521 @default.
• W2886447721 hasAuthorship W2886447721A5053651303 @default.
• W2886447721 hasAuthorship W2886447721A5064894678 @default.
• W2886447721 hasAuthorship W2886447721A5067860180 @default.
• W2886447721 hasAuthorship W2886447721A5071093272 @default.
• W2886447721 hasAuthorship W2886447721A5071389745 @default.
• W2886447721 hasAuthorship W2886447721A5087090947 @default.
• W2886447721 hasBestOaLocation W28864477211 @default.
• W2886447721 hasConcept C126322002 @default.
• W2886447721 hasConcept C134018914 @default.
• W2886447721 hasConcept C142724271 @default.
• W2886447721 hasConcept C170493617 @default.
• W2886447721 hasConcept C185592680 @default.
• W2886447721 hasConcept C196822366 @default.
• W2886447721 hasConcept C203014093 @default.
• W2886447721 hasConcept C204232928 @default.
• W2886447721 hasConcept C2777911890 @default.
• W2886447721 hasConcept C2779726688 @default.
• W2886447721 hasConcept C2780091579 @default.
• W2886447721 hasConcept C2780559512 @default.
• W2886447721 hasConcept C2781115071 @default.
• W2886447721 hasConcept C34688535 @default.
• W2886447721 hasConcept C49802076 @default.
• W2886447721 hasConcept C71315377 @default.
• W2886447721 hasConcept C71924100 @default.
• W2886447721 hasConceptScore W2886447721C126322002 @default.
• W2886447721 hasConceptScore W2886447721C134018914 @default.
• W2886447721 hasConceptScore W2886447721C142724271 @default.
• W2886447721 hasConceptScore W2886447721C170493617 @default.
• W2886447721 hasConceptScore W2886447721C185592680 @default.
• W2886447721 hasConceptScore W2886447721C196822366 @default.
• W2886447721 hasConceptScore W2886447721C203014093 @default.
• W2886447721 hasConceptScore W2886447721C204232928 @default.
• W2886447721 hasConceptScore W2886447721C2777911890 @default.
• W2886447721 hasConceptScore W2886447721C2779726688 @default.
• W2886447721 hasConceptScore W2886447721C2780091579 @default.
• W2886447721 hasConceptScore W2886447721C2780559512 @default.
• W2886447721 hasConceptScore W2886447721C2781115071 @default.
• W2886447721 hasConceptScore W2886447721C34688535 @default.
• W2886447721 hasConceptScore W2886447721C49802076 @default.
• W2886447721 hasConceptScore W2886447721C71315377 @default.
• W2886447721 hasConceptScore W2886447721C71924100 @default.
• W2886447721 hasLocation W28864477211 @default.
• W2886447721 hasLocation W28864477212 @default.
• W2886447721 hasOpenAccess W2886447721 @default.
• W2886447721 hasPrimaryLocation W28864477211 @default.
• W2886447721 hasRelatedWork W1982508091 @default.
• W2886447721 hasRelatedWork W2005311770 @default.
• W2886447721 hasRelatedWork W2007974967 @default.
• W2886447721 hasRelatedWork W2013644072 @default.
• W2886447721 hasRelatedWork W2014764273 @default.
• W2886447721 hasRelatedWork W2036279898 @default.
• W2886447721 hasRelatedWork W2047199006 @default.

• next