Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886470805> ?p ?o ?g. }
- W2886470805 abstract "Abstract Major depressive disorder (MDD) is a complex illness that involves the interaction of different brain systems, pathways, and cell types. Past molecular studies of MDD relied on cellular homogenates of post-mortem brain tissue, making it impossible to determine gene expression changes within individual cells. Using single-cell transcriptomics, we examined almost 80,000 nuclei from the dorsolateral prefrontal cortex of individuals with MDD and healthy controls. Our analyses identified 26 distinct cellular clusters, and over 60% of these showed transcriptional differences between groups. Specifically, 96 genes were differentially expressed, the majority of which were downregulated. Convergent evidence from our analyses, including gene expression, differential correlation, and gene ontology implicated dysregulation of synaptic plasticity in the etiopathogenesis of MDD. Our results show that this high-resolution approach can reveal previously undetectable changes in specific cell types in the context of complex phenotypes and heterogeneous tissues." @default.
- W2886470805 created "2018-08-22" @default.
- W2886470805 creator A5028137500 @default.
- W2886470805 creator A5033098260 @default.
- W2886470805 creator A5036446265 @default.
- W2886470805 creator A5042451792 @default.
- W2886470805 creator A5044600248 @default.
- W2886470805 creator A5050728137 @default.
- W2886470805 creator A5070936342 @default.
- W2886470805 creator A5074956355 @default.
- W2886470805 date "2018-08-03" @default.
- W2886470805 modified "2023-09-24" @default.
- W2886470805 title "Single-nucleus RNA sequencing shows convergent evidence from different cell types for altered synaptic plasticity in major depressive disorder" @default.
- W2886470805 cites W1519075624 @default.
- W2886470805 cites W1966911546 @default.
- W2886470805 cites W1971324097 @default.
- W2886470805 cites W1973093449 @default.
- W2886470805 cites W1979283544 @default.
- W2886470805 cites W1983064746 @default.
- W2886470805 cites W1984883254 @default.
- W2886470805 cites W1987836975 @default.
- W2886470805 cites W1994630549 @default.
- W2886470805 cites W1995185151 @default.
- W2886470805 cites W2000551557 @default.
- W2886470805 cites W2010153547 @default.
- W2886470805 cites W2010473698 @default.
- W2886470805 cites W2016740368 @default.
- W2886470805 cites W2022809747 @default.
- W2886470805 cites W2052882299 @default.
- W2886470805 cites W2055655674 @default.
- W2886470805 cites W2056376421 @default.
- W2886470805 cites W2058915525 @default.
- W2886470805 cites W2073248815 @default.
- W2886470805 cites W2074661552 @default.
- W2886470805 cites W2091520483 @default.
- W2886470805 cites W2094997319 @default.
- W2886470805 cites W2097580689 @default.
- W2886470805 cites W2101791610 @default.
- W2886470805 cites W2102212449 @default.
- W2886470805 cites W2103993795 @default.
- W2886470805 cites W2110921107 @default.
- W2886470805 cites W2112630596 @default.
- W2886470805 cites W2145364268 @default.
- W2886470805 cites W2150002111 @default.
- W2886470805 cites W2151409320 @default.
- W2886470805 cites W2158549544 @default.
- W2886470805 cites W2158804744 @default.
- W2886470805 cites W2176978669 @default.
- W2886470805 cites W2291443053 @default.
- W2886470805 cites W2346233443 @default.
- W2886470805 cites W2471513101 @default.
- W2886470805 cites W2518593643 @default.
- W2886470805 cites W2519269112 @default.
- W2886470805 cites W2522047461 @default.
- W2886470805 cites W2558424111 @default.
- W2886470805 cites W2559466477 @default.
- W2886470805 cites W2573028465 @default.
- W2886470805 cites W2730900010 @default.
- W2886470805 cites W2734414396 @default.
- W2886470805 cites W2738082385 @default.
- W2886470805 cites W2747841296 @default.
- W2886470805 cites W2754537121 @default.
- W2886470805 cites W2765925057 @default.
- W2886470805 cites W2793922811 @default.
- W2886470805 cites W2794480084 @default.
- W2886470805 cites W2795431931 @default.
- W2886470805 cites W2803958441 @default.
- W2886470805 cites W2951506174 @default.
- W2886470805 cites W2952602120 @default.
- W2886470805 cites W2952673268 @default.
- W2886470805 cites W3099195087 @default.
- W2886470805 doi "https://doi.org/10.1101/384479" @default.
- W2886470805 hasPublicationYear "2018" @default.
- W2886470805 type Work @default.
- W2886470805 sameAs 2886470805 @default.
- W2886470805 citedByCount "8" @default.
- W2886470805 countsByYear W28864708052018 @default.
- W2886470805 countsByYear W28864708052019 @default.
- W2886470805 countsByYear W28864708052020 @default.
- W2886470805 countsByYear W28864708052022 @default.
- W2886470805 crossrefType "posted-content" @default.
- W2886470805 hasAuthorship W2886470805A5028137500 @default.
- W2886470805 hasAuthorship W2886470805A5033098260 @default.
- W2886470805 hasAuthorship W2886470805A5036446265 @default.
- W2886470805 hasAuthorship W2886470805A5042451792 @default.
- W2886470805 hasAuthorship W2886470805A5044600248 @default.
- W2886470805 hasAuthorship W2886470805A5050728137 @default.
- W2886470805 hasAuthorship W2886470805A5070936342 @default.
- W2886470805 hasAuthorship W2886470805A5074956355 @default.
- W2886470805 hasBestOaLocation W28864708051 @default.
- W2886470805 hasConcept C104317684 @default.
- W2886470805 hasConcept C127716648 @default.
- W2886470805 hasConcept C1491633281 @default.
- W2886470805 hasConcept C150194340 @default.
- W2886470805 hasConcept C151730666 @default.
- W2886470805 hasConcept C162317418 @default.
- W2886470805 hasConcept C169760540 @default.
- W2886470805 hasConcept C169900460 @default.
- W2886470805 hasConcept C170493617 @default.
- W2886470805 hasConcept C189014844 @default.