Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886477044> ?p ?o ?g. }
- W2886477044 endingPage "363" @default.
- W2886477044 startingPage "354" @default.
- W2886477044 abstract "Titanium dioxide is “generally regarded as safe” and titanium dioxide nanoparticles (TiO2 NPs) are used in a wide variety of consumer products. Cellular exposure to TiO2 NPs results in complex effects on cell physiology including induction of oxidative stress and impairment of lysosomal function, raising concerns about the impact of TiO2 NPs on biological systems. We investigated the effects of TiO2 NPs (15, 50, and 100 nm in diameter) on the lysosome-autophagy system, the main cellular catabolic pathway that mediates degradation of nanomaterials. Specifically, we monitored a comprehensive set of markers of the lysosome-autophagy system upon cell exposure to TiO2 NPs, ranging from transcriptional activation of genes required for the formation of autophagic vesicles to clearance of autophagic substrates. This study reveals that uptake of TiO2 NPs induces a response of the lysosome-autophagy system mediated by the transcription factor EB and consequent upregulation of the autophagic flux. Prolonged exposure to TiO2 NPs, however, was found to induce lysosomal dysfunction and membrane permeabilization, leading to a blockage in autophagic flux. Results from this study will inform the design of TiO2 NP based devices with specific autophagy-modulating properties." @default.
- W2886477044 created "2018-08-22" @default.
- W2886477044 creator A5009756573 @default.
- W2886477044 creator A5042887348 @default.
- W2886477044 creator A5071607276 @default.
- W2886477044 creator A5077042737 @default.
- W2886477044 date "2018-10-01" @default.
- W2886477044 modified "2023-10-16" @default.
- W2886477044 title "Autophagic response to cellular exposure to titanium dioxide nanoparticles" @default.
- W2886477044 cites W1160326939 @default.
- W2886477044 cites W1267363570 @default.
- W2886477044 cites W1549104816 @default.
- W2886477044 cites W1670684017 @default.
- W2886477044 cites W1678795445 @default.
- W2886477044 cites W1875936957 @default.
- W2886477044 cites W1963521777 @default.
- W2886477044 cites W1965205152 @default.
- W2886477044 cites W1965709240 @default.
- W2886477044 cites W1970661950 @default.
- W2886477044 cites W1977767269 @default.
- W2886477044 cites W1982475443 @default.
- W2886477044 cites W1987720329 @default.
- W2886477044 cites W1987769185 @default.
- W2886477044 cites W1990138203 @default.
- W2886477044 cites W1992272543 @default.
- W2886477044 cites W1993239362 @default.
- W2886477044 cites W1995777867 @default.
- W2886477044 cites W1996844579 @default.
- W2886477044 cites W2001797110 @default.
- W2886477044 cites W2002003950 @default.
- W2886477044 cites W2009926632 @default.
- W2886477044 cites W2022884184 @default.
- W2886477044 cites W2028921565 @default.
- W2886477044 cites W2029533392 @default.
- W2886477044 cites W2037959286 @default.
- W2886477044 cites W2039641252 @default.
- W2886477044 cites W2045713968 @default.
- W2886477044 cites W2048711221 @default.
- W2886477044 cites W2056084922 @default.
- W2886477044 cites W2069467605 @default.
- W2886477044 cites W2075409966 @default.
- W2886477044 cites W2077499130 @default.
- W2886477044 cites W2077731318 @default.
- W2886477044 cites W2080637633 @default.
- W2886477044 cites W2088789315 @default.
- W2886477044 cites W2089230333 @default.
- W2886477044 cites W2091049385 @default.
- W2886477044 cites W2094622646 @default.
- W2886477044 cites W2095706874 @default.
- W2886477044 cites W2097170834 @default.
- W2886477044 cites W2108615682 @default.
- W2886477044 cites W2116505693 @default.
- W2886477044 cites W2124733101 @default.
- W2886477044 cites W2137746475 @default.
- W2886477044 cites W2141864709 @default.
- W2886477044 cites W2155687923 @default.
- W2886477044 cites W2173401745 @default.
- W2886477044 cites W2320616821 @default.
- W2886477044 cites W2323960045 @default.
- W2886477044 cites W2404820196 @default.
- W2886477044 cites W2549111609 @default.
- W2886477044 cites W2554728928 @default.
- W2886477044 cites W2620308941 @default.
- W2886477044 cites W2729977904 @default.
- W2886477044 doi "https://doi.org/10.1016/j.actbio.2018.08.021" @default.
- W2886477044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30134208" @default.
- W2886477044 hasPublicationYear "2018" @default.
- W2886477044 type Work @default.
- W2886477044 sameAs 2886477044 @default.
- W2886477044 citedByCount "27" @default.
- W2886477044 countsByYear W28864770442018 @default.
- W2886477044 countsByYear W28864770442019 @default.
- W2886477044 countsByYear W28864770442020 @default.
- W2886477044 countsByYear W28864770442021 @default.
- W2886477044 countsByYear W28864770442022 @default.
- W2886477044 countsByYear W28864770442023 @default.
- W2886477044 crossrefType "journal-article" @default.
- W2886477044 hasAuthorship W2886477044A5009756573 @default.
- W2886477044 hasAuthorship W2886477044A5042887348 @default.
- W2886477044 hasAuthorship W2886477044A5071607276 @default.
- W2886477044 hasAuthorship W2886477044A5077042737 @default.
- W2886477044 hasConcept C104317684 @default.
- W2886477044 hasConcept C12554922 @default.
- W2886477044 hasConcept C127561419 @default.
- W2886477044 hasConcept C181199279 @default.
- W2886477044 hasConcept C185592680 @default.
- W2886477044 hasConcept C190283241 @default.
- W2886477044 hasConcept C192562407 @default.
- W2886477044 hasConcept C203522944 @default.
- W2886477044 hasConcept C2776151105 @default.
- W2886477044 hasConcept C2780216420 @default.
- W2886477044 hasConcept C55493867 @default.
- W2886477044 hasConcept C86803240 @default.
- W2886477044 hasConcept C95444343 @default.
- W2886477044 hasConceptScore W2886477044C104317684 @default.
- W2886477044 hasConceptScore W2886477044C12554922 @default.
- W2886477044 hasConceptScore W2886477044C127561419 @default.
- W2886477044 hasConceptScore W2886477044C181199279 @default.