FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886477432> ?p ?o ?g. }

• W2886477432 endingPage "596" @default.
• W2886477432 startingPage "587" @default.
• W2886477432 abstract "Autoimmune hepatitis (AIH) is considered less common in the Asia Pacific region. Due to this, AIH flare as a cause of acute on chronic liver failure (ACLF) is often overlooked and treatment delayed. We aimed at the defining clinical and histopathological spectrum and role of steroid therapy in AIH-ACLF. Patients with AIH-ACLF, prospectively recruited and followed between 2012 and 2017, were analyzed from the Asian Pacific Association for the Study of the Liver ACLF Research Consortium (AARC) data base. Diagnosis of AIH was confirmed using International Autoimmune Hepatitis Group score or simplified AIH score with histopathological evidence. Of 2,825 ACLF patients, 82 (2.9%) fulfilled criteria of AIH (age 42.1 ± 18.1 years, 70% female). At baseline, mean bilirubin was 18.6 ± 8.2 mg/dL, Child-Turcotte-Pugh score was 11.7 ± 1.4, and Model for End-Stage Liver Disease (MELD) score was 27.6 ± 6.5. Mean immunoglobulin G was 21.61 ± 7.32 g/dL, and this was elevated ≥1.1 times in 97% of cases; 49% were seronegative. Liver histology was available in 90%, with median histological activity index of 10 (interquartile range, 7-12); 90% with moderate to severe interface activity; 56% showing significant parenchymal necrosis (bridging and confluent necrosis); and cirrhosis in 42%. Twenty-eight (34%) patients received steroid therapy and showed shorter intensive care unit (ICU) stay (median 1.5 versus 4 days, P < 0.001) and improved 90-day survival (75% versus 48.1%, P = 0.02) with comparable incidence of sepsis (P = 0.32) compared to those who did not. Patients of advanced age, more severe liver disease (MELD >27; 83.3% sensitivity, 78.9% specificity, area under the receiver operating characteristic curve 0.86), presence of hepatic encephalopathy, and fibrosis grade ≥F3 had an unfavorable response to corticosteroid therapy. Conclusion: AIH presenting as ACLF is not uncommon in Asian patients; a low threshold for liver biopsy is needed to confirm the diagnosis as nearly half the patients are seronegative; early stratification to steroid therapy or liver transplantation (MELD >27, hepatic encephalopathy in ≥F3) would reduce ICU stay and improve outcomes." @default.
• W2886477432 created "2018-08-22" @default.
• W2886477432 creator A5001027718 @default.
• W2886477432 creator A5004402988 @default.
• W2886477432 creator A5007162667 @default.
• W2886477432 creator A5008698250 @default.
• W2886477432 creator A5026415059 @default.
• W2886477432 creator A5028481134 @default.
• W2886477432 creator A5032313672 @default.
• W2886477432 creator A5034157022 @default.
• W2886477432 creator A5034427331 @default.
• W2886477432 creator A5036056002 @default.
• W2886477432 creator A5037146001 @default.
• W2886477432 creator A5038267980 @default.
• W2886477432 creator A5038348038 @default.
• W2886477432 creator A5039911853 @default.
• W2886477432 creator A5041891746 @default.
• W2886477432 creator A5049920455 @default.
• W2886477432 creator A5052676364 @default.
• W2886477432 creator A5053309160 @default.
• W2886477432 creator A5054809763 @default.
• W2886477432 creator A5056571923 @default.
• W2886477432 creator A5058077403 @default.
• W2886477432 creator A5064549446 @default.
• W2886477432 creator A5068701943 @default.
• W2886477432 creator A5071567530 @default.
• W2886477432 creator A5078805238 @default.
• W2886477432 creator A5082826764 @default.
• W2886477432 creator A5084289251 @default.
• W2886477432 creator A5085448958 @default.
• W2886477432 creator A5086102330 @default.
• W2886477432 creator A5087644825 @default.
• W2886477432 date "2019-02-22" @default.
• W2886477432 modified "2023-09-23" @default.
• W2886477432 title "Flare of Autoimmune Hepatitis Causing Acute on Chronic Liver Failure: Diagnosis and Response to Corticosteroid Therapy" @default.
• W2886477432 cites W1576316074 @default.
• W2886477432 cites W1727809390 @default.
• W2886477432 cites W1973130325 @default.
• W2886477432 cites W1973339766 @default.
• W2886477432 cites W1980989647 @default.
• W2886477432 cites W1996015553 @default.
• W2886477432 cites W2000484633 @default.
• W2886477432 cites W2009264645 @default.
• W2886477432 cites W2033215669 @default.
• W2886477432 cites W2036716972 @default.
• W2886477432 cites W2041914872 @default.
• W2886477432 cites W2050642916 @default.
• W2886477432 cites W2055202209 @default.
• W2886477432 cites W2068123329 @default.
• W2886477432 cites W2068902509 @default.
• W2886477432 cites W2069258996 @default.
• W2886477432 cites W2075259610 @default.
• W2886477432 cites W2095521775 @default.
• W2886477432 cites W2111368337 @default.
• W2886477432 cites W2112740038 @default.
• W2886477432 cites W2113857853 @default.
• W2886477432 cites W2121191489 @default.
• W2886477432 cites W2128062619 @default.
• W2886477432 cites W2132675308 @default.
• W2886477432 cites W2165174299 @default.
• W2886477432 cites W2166497420 @default.
• W2886477432 cites W2168271603 @default.
• W2886477432 cites W2170705556 @default.
• W2886477432 cites W2318019824 @default.
• W2886477432 cites W2461293867 @default.
• W2886477432 cites W2521052824 @default.
• W2886477432 cites W2592783804 @default.
• W2886477432 cites W4210992623 @default.
• W2886477432 doi "https://doi.org/10.1002/hep.30205" @default.
• W2886477432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30113706" @default.
• W2886477432 hasPublicationYear "2019" @default.
• W2886477432 type Work @default.
• W2886477432 sameAs 2886477432 @default.
• W2886477432 citedByCount "49" @default.
• W2886477432 countsByYear W28864774322019 @default.
• W2886477432 countsByYear W28864774322020 @default.
• W2886477432 countsByYear W28864774322021 @default.
• W2886477432 countsByYear W28864774322022 @default.
• W2886477432 countsByYear W28864774322023 @default.
• W2886477432 crossrefType "journal-article" @default.
• W2886477432 hasAuthorship W2886477432A5001027718 @default.
• W2886477432 hasAuthorship W2886477432A5004402988 @default.
• W2886477432 hasAuthorship W2886477432A5007162667 @default.
• W2886477432 hasAuthorship W2886477432A5008698250 @default.
• W2886477432 hasAuthorship W2886477432A5026415059 @default.
• W2886477432 hasAuthorship W2886477432A5028481134 @default.
• W2886477432 hasAuthorship W2886477432A5032313672 @default.
• W2886477432 hasAuthorship W2886477432A5034157022 @default.
• W2886477432 hasAuthorship W2886477432A5034427331 @default.
• W2886477432 hasAuthorship W2886477432A5036056002 @default.
• W2886477432 hasAuthorship W2886477432A5037146001 @default.
• W2886477432 hasAuthorship W2886477432A5038267980 @default.
• W2886477432 hasAuthorship W2886477432A5038348038 @default.
• W2886477432 hasAuthorship W2886477432A5039911853 @default.
• W2886477432 hasAuthorship W2886477432A5041891746 @default.
• W2886477432 hasAuthorship W2886477432A5049920455 @default.
• W2886477432 hasAuthorship W2886477432A5052676364 @default.
• W2886477432 hasAuthorship W2886477432A5053309160 @default.

• next