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- W2886499486 abstract "Five coumarins (5,7,8-trimethoxycoumarin (1), sabandin (2), cubreuva lactone (3), 5,7-dimethoxycoumarin (5) and braylin (6)), seven furoquinoline alkaloids (isopimpinelin (4), pteleine (7), maculine (8), skimianine (10), robustine (11), y-fagarine (12) and dictamine (13) and the furofuran type lignin syringaresinol (9)) have been identified for the first time in the roots of Zanthoxylum tingoassuiba A. St.-Hil., Rutaceae. Pure compounds 1, 6, 9, 12 were tested against Leishmania amazonensis parasites and epimastigotes forms of Trypanosoma cruzi. All the tested products displayed an antiparasitic activity similar to that of the positive controls (benznidazole and amphotericin B). Compound 9 was the most active against both parasites with IC50 values of 11.98 μM and 7.55 μM against L. amazonensis and T. cruzi, respectively." @default.
- W2886499486 created "2018-08-22" @default.
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- W2886499486 date "2018-09-01" @default.
- W2886499486 modified "2023-09-27" @default.
- W2886499486 title "In vitro antileishmanial and antitrypanosomal activity of compounds isolated from the roots of Zanthoxylum tingoassuiba" @default.
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- W2886499486 doi "https://doi.org/10.1016/j.bjp.2018.04.013" @default.
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