Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886511473> ?p ?o ?g. }
- W2886511473 endingPage "3392" @default.
- W2886511473 startingPage "3378" @default.
- W2886511473 abstract "Summary Sec4/Rab8 is one of the well‐studied members of the Rab GTPase family, previous studies have shown that Sec4/Rab8 crucially promotes the pathogenesis of phytopathogens, but the upstream regulators of Rab8 are still unknown. Here, we have identified two Sec2 homologues FgSec2A and FgSec2B in devastating fungal pathogen Fusarium graminearum and investigated their functions and interactions with FgRab8 by live‐cell imaging, genetic and functional analyses. Yeast two‐hybrid assay shows that FgSec2A specifically interacts with FgRab8DN(N123I) and itself. Importantly, FgSec2A is required for growth, conidiation, DON production and virulence of F. graminearum . Live‐cell imaging shows that FgSec2A and FgSec2B are both localized to the tip region of hyphae and conidia. Both N‐terminal region and Sec2 domain of FgSec2A are essential for its function, but not for localization, whereas the C‐terminal region is important for its polarized localization. Furthermore, constitutively active FgRab8CA(Q69L) partially rescues the defects of Δ Fgsec2A . Consistently, FgSec2A is required for the polarized localization of FgRab8. Finally, FgSec2A and FgSec2B show partial functions, but FgSec2A does not interact and co‐localize with FgSec2B. Taken together, these results indicate that FgSec2A acts as a FgRab8 guanine nucleotide exchange factor and is necessary for polarized growth, DON production and pathogenicity in F. graminearum ." @default.
- W2886511473 created "2018-08-22" @default.
- W2886511473 creator A5011362260 @default.
- W2886511473 creator A5017840696 @default.
- W2886511473 creator A5021588519 @default.
- W2886511473 creator A5031784602 @default.
- W2886511473 creator A5036114336 @default.
- W2886511473 creator A5041215731 @default.
- W2886511473 creator A5046561927 @default.
- W2886511473 creator A5049628095 @default.
- W2886511473 creator A5054616519 @default.
- W2886511473 creator A5073218509 @default.
- W2886511473 creator A5081460516 @default.
- W2886511473 creator A5091833058 @default.
- W2886511473 date "2018-09-01" @default.
- W2886511473 modified "2023-09-30" @default.
- W2886511473 title "FgSec2A, a guanine nucleotide exchange factor of FgRab8, is important for polarized growth, pathogenicity and deoxynivalenol production in <i>Fusarium graminearum</i>" @default.
- W2886511473 cites W1595083713 @default.
- W2886511473 cites W1631754845 @default.
- W2886511473 cites W1825202194 @default.
- W2886511473 cites W1892404048 @default.
- W2886511473 cites W1976543073 @default.
- W2886511473 cites W2001918182 @default.
- W2886511473 cites W2015768652 @default.
- W2886511473 cites W2026273381 @default.
- W2886511473 cites W2030445913 @default.
- W2886511473 cites W2044113522 @default.
- W2886511473 cites W2047791387 @default.
- W2886511473 cites W2053353491 @default.
- W2886511473 cites W2059506482 @default.
- W2886511473 cites W2059775037 @default.
- W2886511473 cites W2069329269 @default.
- W2886511473 cites W2069354876 @default.
- W2886511473 cites W2074147706 @default.
- W2886511473 cites W2077091529 @default.
- W2886511473 cites W2090486711 @default.
- W2886511473 cites W2090778735 @default.
- W2886511473 cites W2097751621 @default.
- W2886511473 cites W2101972427 @default.
- W2886511473 cites W2106350501 @default.
- W2886511473 cites W2110866976 @default.
- W2886511473 cites W2119914706 @default.
- W2886511473 cites W2124259255 @default.
- W2886511473 cites W2124603595 @default.
- W2886511473 cites W2125603035 @default.
- W2886511473 cites W2129741405 @default.
- W2886511473 cites W2139794982 @default.
- W2886511473 cites W2146795855 @default.
- W2886511473 cites W2147820111 @default.
- W2886511473 cites W2148520503 @default.
- W2886511473 cites W2155420810 @default.
- W2886511473 cites W2157091601 @default.
- W2886511473 cites W2157209798 @default.
- W2886511473 cites W2167153850 @default.
- W2886511473 cites W2195158808 @default.
- W2886511473 cites W2195317181 @default.
- W2886511473 cites W2281494282 @default.
- W2886511473 cites W2406985299 @default.
- W2886511473 cites W2526772857 @default.
- W2886511473 cites W2544352050 @default.
- W2886511473 cites W2556975090 @default.
- W2886511473 cites W2593492412 @default.
- W2886511473 cites W2744120533 @default.
- W2886511473 cites W2748824260 @default.
- W2886511473 cites W2884018351 @default.
- W2886511473 doi "https://doi.org/10.1111/1462-2920.14373" @default.
- W2886511473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30105886" @default.
- W2886511473 hasPublicationYear "2018" @default.
- W2886511473 type Work @default.
- W2886511473 sameAs 2886511473 @default.
- W2886511473 citedByCount "26" @default.
- W2886511473 countsByYear W28865114732019 @default.
- W2886511473 countsByYear W28865114732020 @default.
- W2886511473 countsByYear W28865114732021 @default.
- W2886511473 countsByYear W28865114732022 @default.
- W2886511473 countsByYear W28865114732023 @default.
- W2886511473 crossrefType "journal-article" @default.
- W2886511473 hasAuthorship W2886511473A5011362260 @default.
- W2886511473 hasAuthorship W2886511473A5017840696 @default.
- W2886511473 hasAuthorship W2886511473A5021588519 @default.
- W2886511473 hasAuthorship W2886511473A5031784602 @default.
- W2886511473 hasAuthorship W2886511473A5036114336 @default.
- W2886511473 hasAuthorship W2886511473A5041215731 @default.
- W2886511473 hasAuthorship W2886511473A5046561927 @default.
- W2886511473 hasAuthorship W2886511473A5049628095 @default.
- W2886511473 hasAuthorship W2886511473A5054616519 @default.
- W2886511473 hasAuthorship W2886511473A5073218509 @default.
- W2886511473 hasAuthorship W2886511473A5081460516 @default.
- W2886511473 hasAuthorship W2886511473A5091833058 @default.
- W2886511473 hasConcept C104317684 @default.
- W2886511473 hasConcept C126619667 @default.
- W2886511473 hasConcept C156728348 @default.
- W2886511473 hasConcept C190062978 @default.
- W2886511473 hasConcept C207332259 @default.
- W2886511473 hasConcept C2777576037 @default.
- W2886511473 hasConcept C2779347548 @default.
- W2886511473 hasConcept C2781090273 @default.
- W2886511473 hasConcept C2910135453 @default.