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- W28865656 abstract "This chapter focuses on the regeneration of mammalian liver. Regeneration is commonly employed to describe the compensatory hypertrophy and hyperplasia that occur in liver in response to damage or loss of tissue. The chapter reviews experimental studies on the homeostatic control of hepatic growth, as exemplified primarily by regeneration in response to partial hepatectomy, with particular attention to the first cycle of cellular growth and division. Modifications of the regenerative response have been examined with particular attention to the control of variables. In addition to the usual environmental, dietary, genetic, and endocrine factors that may affect certain aspects of the process, attention is called to the fact that the times at which mitosis, and DNA synthesis reach their peaks vary significantly with the age of the animal. The degree of liver deficiency determines the extent of response above a certain threshold and the latter is much lower in young, rapidly growing rats. In a similar vein, techniques of evaluating the regenerative response are discussed with emphasis on the sources of error and drawbacks inherent in each. DNA synthesis, which is prerequisite to mitosis and of central importance in cellular proliferation, is discussed with emphasis on the interplay of various component reactions and points at which the process might be subject to regulation." @default.
- W28865656 created "2016-06-24" @default.
- W28865656 creator A5061326442 @default.
- W28865656 date "1963-01-01" @default.
- W28865656 modified "2023-10-03" @default.
- W28865656 title "Regeneration of Mammalian Liver" @default.
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