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- W2886572093 abstract "Melanoma, the most dangerous skin cancer, originates from the melanocytes and has a high tendency to invade neighboring tissues, and metastasize. Both antioxidant and pro-oxidant appear to be involved in modulating melanocyte transformation, melanoma progression and invasion. Consequently, potent antioxidants and pro-oxidant may prevent cell transformation and tumor progression. Skin melanoma the most common malignancy in United States there are 2 million cases diagnosed in US annually. Among the novel therapies there is the use of bioactive compounds, which have proven to show increase response (IRR) and overall survival (OS) rates. In fact, Dacarbazine is the only FDA approved chemotherapeutic bioactive compound for melanoma treatment. We have identified eight bioactive compounds with antioxidant and pro-oxidative activities as anti-melanoma/anti-invasion agents. They were previously found to posse’s in vitro antioxidant or pro-oxidant activity, Compounds 1, 2, 3, 4, 5, 6, 7 and 8 were found to be most potent anti-melanoma agent. These compounds are now tested for intracellular free radical quenching and ROS producing role in skin melanoma cells in vitro and their ability to reduce proliferation and spreading." @default.
- W2886572093 created "2018-08-22" @default.
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- W2886572093 date "2018-08-01" @default.
- W2886572093 modified "2023-10-16" @default.
- W2886572093 title "New small molecular weight antioxidants and pro-oxidants control melanoma cell proliferation and spreading in vitro" @default.
- W2886572093 doi "https://doi.org/10.1016/j.freeradbiomed.2018.05.050" @default.
- W2886572093 hasPublicationYear "2018" @default.
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