FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886579043> ?p ?o ?g. }

• W2886579043 endingPage "1224" @default.
• W2886579043 startingPage "1214" @default.
• W2886579043 abstract "Associated Multimedia BACKGROUND Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration. OBJECTIVE To determine if fluorescence represents a prognostic marker in LGG. METHODS Seventy-four consecutive patients with LGG (World Health Organization 2016) were operated on with 5-ALA. Fluorescent tissue was specifically biopsied. Tumor size, age, Karnofsky index, contrast-enhancement, fluorescence, and molecular factors (IDH1/IDH2-mutations, Ki67/MIB1 Index, 1p19q codeletions, ATRX, EGFR, p53 expression, and O6-methylguanine DNA methyltransferase promotor methylation), were related to progression-free survival (PFS), malignant transformation-free survival (MTFS) and overall survival (OS). RESULTS Sixteen of seventy-four LGGs (21.6%) fluoresced. Fluorescence was partially related to weak enhancement on magnetic resonance imaging and increased (positron emission tomography)PET-FET uptake, but not to Karnofsky Performance Score, tumor size, or age. Regarding molecular markers, only EGFR expression differed marginally (fluorescing vs nonfluorescing: 19% vs 5%; P = .057). Median follow-up was 46.4 mo (95% confidence interval [CI]: 41.8-51.1). PFS, MTFS, and OS were shorter in fluorescing tumors (PFS: median 9.8 mo, 95% CI: 1.00-27.7 vs 45.8, 31.9-59.7, MTFS: 43.0 [27.5-58.5] vs 64.6 [57.7-71.5], median not reached, P = .015; OS: 51.6, [34.8-68.3] vs [68.2, 62.7-73.8], P = .002). IDH mutations significantly predicted PFS, MTFS, and OS. In multivariate analysis IDH status and fluorescence both independently predicted MTFS and OS. PFS was not independently predicted by fluorescence. CONCLUSION This is the first report investigating the role of ALA-induced fluorescence in histologically confirmed LGG. Fluorescence appeared to be a marker for inherent malignant transformation and OS, independently of known prognostic markers. Fluorescence in LGG might be taken into account when deciding on adjuvant therapies." @default.
• W2886579043 created "2018-08-22" @default.
• W2886579043 creator A5021457931 @default.
• W2886579043 creator A5024124953 @default.
• W2886579043 creator A5032197296 @default.
• W2886579043 creator A5037103226 @default.
• W2886579043 creator A5047619883 @default.
• W2886579043 creator A5049694972 @default.
• W2886579043 creator A5056369695 @default.
• W2886579043 creator A5064834985 @default.
• W2886579043 date "2018-08-09" @default.
• W2886579043 modified "2023-09-27" @default.
• W2886579043 title "Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?" @default.
• W2886579043 cites W1547034917 @default.
• W2886579043 cites W1569307548 @default.
• W2886579043 cites W1585100542 @default.
• W2886579043 cites W1608734166 @default.
• W2886579043 cites W1850380680 @default.
• W2886579043 cites W1891095862 @default.
• W2886579043 cites W1960834400 @default.
• W2886579043 cites W1975839853 @default.
• W2886579043 cites W1976490482 @default.
• W2886579043 cites W1993683901 @default.
• W2886579043 cites W1996319332 @default.
• W2886579043 cites W1997502785 @default.
• W2886579043 cites W2001247750 @default.
• W2886579043 cites W2007425554 @default.
• W2886579043 cites W2007878052 @default.
• W2886579043 cites W2012168402 @default.
• W2886579043 cites W2046899111 @default.
• W2886579043 cites W2052566050 @default.
• W2886579043 cites W2053882060 @default.
• W2886579043 cites W2054683189 @default.
• W2886579043 cites W2057120578 @default.
• W2886579043 cites W2057238766 @default.
• W2886579043 cites W2062079114 @default.
• W2886579043 cites W2063825033 @default.
• W2886579043 cites W2066851587 @default.
• W2886579043 cites W2070725664 @default.
• W2886579043 cites W2071221139 @default.
• W2886579043 cites W2076223514 @default.
• W2886579043 cites W2078918817 @default.
• W2886579043 cites W2086324872 @default.
• W2886579043 cites W2094978295 @default.
• W2886579043 cites W2098723369 @default.
• W2886579043 cites W2103615847 @default.
• W2886579043 cites W2107007091 @default.
• W2886579043 cites W2108309130 @default.
• W2886579043 cites W2115689917 @default.
• W2886579043 cites W2125372543 @default.
• W2886579043 cites W2130553763 @default.
• W2886579043 cites W2131385778 @default.
• W2886579043 cites W2132369953 @default.
• W2886579043 cites W2135282485 @default.
• W2886579043 cites W2135575642 @default.
• W2886579043 cites W2141699748 @default.
• W2886579043 cites W2146991912 @default.
• W2886579043 cites W2147387301 @default.
• W2886579043 cites W2166847050 @default.
• W2886579043 cites W2167560492 @default.
• W2886579043 cites W2168784615 @default.
• W2886579043 cites W2340897492 @default.
• W2886579043 cites W2366536035 @default.
• W2886579043 cites W251588444 @default.
• W2886579043 cites W2530071270 @default.
• W2886579043 cites W2594733019 @default.
• W2886579043 cites W2604398481 @default.
• W2886579043 cites W2625826824 @default.
• W2886579043 cites W2730877248 @default.
• W2886579043 cites W2767704145 @default.
• W2886579043 cites W2991912205 @default.
• W2886579043 cites W571060166 @default.
• W2886579043 doi "https://doi.org/10.1093/neuros/nyy365" @default.
• W2886579043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6537633" @default.
• W2886579043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30107580" @default.
• W2886579043 hasPublicationYear "2018" @default.
• W2886579043 type Work @default.
• W2886579043 sameAs 2886579043 @default.
• W2886579043 citedByCount "50" @default.
• W2886579043 countsByYear W28865790432018 @default.
• W2886579043 countsByYear W28865790432019 @default.
• W2886579043 countsByYear W28865790432020 @default.
• W2886579043 countsByYear W28865790432021 @default.
• W2886579043 countsByYear W28865790432022 @default.
• W2886579043 countsByYear W28865790432023 @default.
• W2886579043 crossrefType "journal-article" @default.
• W2886579043 hasAuthorship W2886579043A5021457931 @default.
• W2886579043 hasAuthorship W2886579043A5024124953 @default.
• W2886579043 hasAuthorship W2886579043A5032197296 @default.
• W2886579043 hasAuthorship W2886579043A5037103226 @default.
• W2886579043 hasAuthorship W2886579043A5047619883 @default.
• W2886579043 hasAuthorship W2886579043A5049694972 @default.
• W2886579043 hasAuthorship W2886579043A5056369695 @default.
• W2886579043 hasAuthorship W2886579043A5064834985 @default.
• W2886579043 hasBestOaLocation W28865790432 @default.
• W2886579043 hasConcept C104317684 @default.
• W2886579043 hasConcept C126322002 @default.
• W2886579043 hasConcept C126838900 @default.

• next