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• W2886595908 endingPage "498" @default.
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• W2886595908 abstract "Endocrine disrupting chemicals (EDCs), including pesticides and metals, are present in rural areas, endangering the health of exposed populations. This work aimed to investigate the possible association between the exposure to these xenobiotics and thyroid dysfunction in children living in a rural community of Southern Brazil. Fifty-four children aged 5–16 years participated in this study. Peripheral biomarker evaluations were performed in periods of low and high exposure to pesticides. Thyroid ultrasonography was evaluated in the high exposure period. Blood levels of chromium (Cr), manganese (Mn), mercury (Hg), and lead (Pb), as well as hair Pb levels were positively correlated with thyroid stimulating hormone (TSH) concentrations and negatively associated with free thyroxine (fT4) levels in the low exposure period. Prolactin was positively associated with hair Mn in both periods. In the ultrasound tests, the majority of children presented a normal echogenicity of thyroid. Glucose was inversely associated with the biomarker of exposure to cholinesterase inhibitor insecticides, butyrylcholinesterase (BuChE). Lipid profile was above the recommended levels in both periods. In summary, our results show that children environmentally exposed to a mixture of xenobiotics in an agricultural community may have health impairments, especially on thyroid function, dyslipidemia, and glucose homeostasis disruption." @default.
• W2886595908 created "2018-08-22" @default.
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• W2886595908 date "2018-11-01" @default.
• W2886595908 modified "2023-10-11" @default.
• W2886595908 title "Exposure to environment chemicals and its possible role in endocrine disruption of children from a rural area" @default.
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• W2886595908 doi "https://doi.org/10.1016/j.envres.2018.07.039" @default.
• W2886595908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30142624" @default.
• W2886595908 hasPublicationYear "2018" @default.
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