FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886597435> ?p ?o ?g. }

• W2886597435 endingPage "1784" @default.
• W2886597435 startingPage "1784" @default.
• W2886597435 abstract "A small library of novel fluorinated N-benzamide enaminones were synthesized and evaluated in a battery of acute preclinical seizure models. Three compounds (GSA 62, TTA 35, and WWB 67) were found to have good anticonvulsant activity in the 6-Hz ‘psychomotor’ 44-mA rodent model. The focus of this study was to elucidate the active analogs’ mode of action on seizure-related molecular targets. Electrophysiology studies were employed to evaluate the compounds’ ability to inhibit neuronal activity in central olfactory neurons, mitral cells, and sensory-like ND7/23 cells, which express an assortment of voltage and ligand-gated ion channels. We did not find any significant effects of the three compounds on action potential generation in mitral cells. The treatment of ND7/23 cells with 50 µM of GSA 62, TTA 35, and WWB 67 generated a significant reduction in the amplitude of whole-cell sodium currents. Similar treatment of ND7/23 cells with these compounds had no effect on T-type calcium currents, indicating that fluorinated N-benzamide enaminone analogs may have a selective effect on voltage-gated sodium channels, but not calcium channels." @default.
• W2886597435 created "2018-08-22" @default.
• W2886597435 creator A5015599632 @default.
• W2886597435 creator A5047208039 @default.
• W2886597435 creator A5052732719 @default.
• W2886597435 creator A5060288098 @default.
• W2886597435 creator A5070156303 @default.
• W2886597435 creator A5088261821 @default.
• W2886597435 date "2018-08-20" @default.
• W2886597435 modified "2023-09-27" @default.
• W2886597435 title "6 Hz Active Anticonvulsant Fluorinated N-Benzamide Enaminones and Their Inhibitory Neuronal Activity" @default.
• W2886597435 cites W1989526036 @default.
• W2886597435 cites W2007511877 @default.
• W2886597435 cites W2011549262 @default.
• W2886597435 cites W2045743305 @default.
• W2886597435 cites W2046259291 @default.
• W2886597435 cites W2051624743 @default.
• W2886597435 cites W2075558810 @default.
• W2886597435 cites W2090051674 @default.
• W2886597435 cites W2100283245 @default.
• W2886597435 cites W2111745101 @default.
• W2886597435 cites W2159631864 @default.
• W2886597435 cites W2180981774 @default.
• W2886597435 cites W2416822871 @default.
• W2886597435 cites W2610530916 @default.
• W2886597435 cites W2629744575 @default.
• W2886597435 cites W2950006986 @default.
• W2886597435 cites W2950449957 @default.
• W2886597435 doi "https://doi.org/10.3390/ijerph15081784" @default.
• W2886597435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6121254" @default.
• W2886597435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30127263" @default.
• W2886597435 hasPublicationYear "2018" @default.
• W2886597435 type Work @default.
• W2886597435 sameAs 2886597435 @default.
• W2886597435 citedByCount "9" @default.
• W2886597435 countsByYear W28865974352019 @default.
• W2886597435 countsByYear W28865974352020 @default.
• W2886597435 countsByYear W28865974352021 @default.
• W2886597435 countsByYear W28865974352022 @default.
• W2886597435 crossrefType "journal-article" @default.
• W2886597435 hasAuthorship W2886597435A5015599632 @default.
• W2886597435 hasAuthorship W2886597435A5047208039 @default.
• W2886597435 hasAuthorship W2886597435A5052732719 @default.
• W2886597435 hasAuthorship W2886597435A5060288098 @default.
• W2886597435 hasAuthorship W2886597435A5070156303 @default.
• W2886597435 hasAuthorship W2886597435A5088261821 @default.
• W2886597435 hasBestOaLocation W28865974351 @default.
• W2886597435 hasConcept C126322002 @default.
• W2886597435 hasConcept C169760540 @default.
• W2886597435 hasConcept C17077164 @default.
• W2886597435 hasConcept C178790620 @default.
• W2886597435 hasConcept C185263204 @default.
• W2886597435 hasConcept C185592680 @default.
• W2886597435 hasConcept C2775858608 @default.
• W2886597435 hasConcept C2778186239 @default.
• W2886597435 hasConcept C2780231548 @default.
• W2886597435 hasConcept C50952357 @default.
• W2886597435 hasConcept C519063684 @default.
• W2886597435 hasConcept C537181965 @default.
• W2886597435 hasConcept C71240020 @default.
• W2886597435 hasConcept C71924100 @default.
• W2886597435 hasConcept C86803240 @default.
• W2886597435 hasConcept C98274493 @default.
• W2886597435 hasConceptScore W2886597435C126322002 @default.
• W2886597435 hasConceptScore W2886597435C169760540 @default.
• W2886597435 hasConceptScore W2886597435C17077164 @default.
• W2886597435 hasConceptScore W2886597435C178790620 @default.
• W2886597435 hasConceptScore W2886597435C185263204 @default.
• W2886597435 hasConceptScore W2886597435C185592680 @default.
• W2886597435 hasConceptScore W2886597435C2775858608 @default.
• W2886597435 hasConceptScore W2886597435C2778186239 @default.
• W2886597435 hasConceptScore W2886597435C2780231548 @default.
• W2886597435 hasConceptScore W2886597435C50952357 @default.
• W2886597435 hasConceptScore W2886597435C519063684 @default.
• W2886597435 hasConceptScore W2886597435C537181965 @default.
• W2886597435 hasConceptScore W2886597435C71240020 @default.
• W2886597435 hasConceptScore W2886597435C71924100 @default.
• W2886597435 hasConceptScore W2886597435C86803240 @default.
• W2886597435 hasConceptScore W2886597435C98274493 @default.
• W2886597435 hasIssue "8" @default.
• W2886597435 hasLocation W28865974351 @default.
• W2886597435 hasLocation W28865974352 @default.
• W2886597435 hasLocation W28865974353 @default.
• W2886597435 hasLocation W28865974354 @default.
• W2886597435 hasLocation W28865974355 @default.
• W2886597435 hasOpenAccess W2886597435 @default.
• W2886597435 hasPrimaryLocation W28865974351 @default.
• W2886597435 hasRelatedWork W1954411904 @default.
• W2886597435 hasRelatedWork W1978195453 @default.
• W2886597435 hasRelatedWork W1991845725 @default.
• W2886597435 hasRelatedWork W1996271525 @default.
• W2886597435 hasRelatedWork W2011847024 @default.
• W2886597435 hasRelatedWork W2036138100 @default.
• W2886597435 hasRelatedWork W2065495483 @default.
• W2886597435 hasRelatedWork W2105553204 @default.
• W2886597435 hasRelatedWork W2415592857 @default.
• W2886597435 hasRelatedWork W4300933520 @default.
• W2886597435 hasVolume "15" @default.

• next