Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886600523> ?p ?o ?g. }
- W2886600523 endingPage "9" @default.
- W2886600523 startingPage "1" @default.
- W2886600523 abstract "Previous studies have shown that apolipoprotein C1 (apoC1)-specific antibodies precipitated hepatitis C virus (HCV) and neutralized HCV infectivity, suggesting that apoC1 is a HCV component. However, the importance of apoC1 in the HCV life cycle has not been experimentally examined. In the present study, we sought to determine the role of apoC1 in the HCV infection and morphogenesis by knocking out the apoC1 gene using the CRISPR/Cas9 system. Strikingly, apoC1 gene knockout markedly enhanced apoE expression. As a result, apoC1 gene knockout per se didn’t significantly affect HCV infection or morphogenesis, probably ascribing to its redundant functions with apoE. However, knockout of apoC1 gene potentiated the impairment of HCV infection and/or morphogenesis by apoE-specific small interfering RNAs. Additionally, a recombinant apoC1 protein efficiently blocked HCV infection. Collectively, these findings suggest that apoC1 and apoE have redundant functions in the HCV infection and morphogenesis." @default.
- W2886600523 created "2018-08-22" @default.
- W2886600523 creator A5032891751 @default.
- W2886600523 creator A5050852420 @default.
- W2886600523 creator A5051406306 @default.
- W2886600523 date "2018-11-01" @default.
- W2886600523 modified "2023-10-07" @default.
- W2886600523 title "Characterization of apolipoprotein C1 in hepatitis C virus infection and morphogenesis" @default.
- W2886600523 cites W1502098572 @default.
- W2886600523 cites W1818706014 @default.
- W2886600523 cites W1880992190 @default.
- W2886600523 cites W1988761191 @default.
- W2886600523 cites W1993690048 @default.
- W2886600523 cites W1998833977 @default.
- W2886600523 cites W2001995220 @default.
- W2886600523 cites W2004817638 @default.
- W2886600523 cites W2006309458 @default.
- W2886600523 cites W2007013372 @default.
- W2886600523 cites W2009911047 @default.
- W2886600523 cites W2015489330 @default.
- W2886600523 cites W2015868830 @default.
- W2886600523 cites W2023402045 @default.
- W2886600523 cites W2024763248 @default.
- W2886600523 cites W2025124945 @default.
- W2886600523 cites W2026051181 @default.
- W2886600523 cites W2028668919 @default.
- W2886600523 cites W2034241642 @default.
- W2886600523 cites W2036306822 @default.
- W2886600523 cites W2041882184 @default.
- W2886600523 cites W2042063943 @default.
- W2886600523 cites W2054862747 @default.
- W2886600523 cites W2066203226 @default.
- W2886600523 cites W2076955144 @default.
- W2886600523 cites W2078364031 @default.
- W2886600523 cites W2078887917 @default.
- W2886600523 cites W2079724990 @default.
- W2886600523 cites W2084858225 @default.
- W2886600523 cites W2087583050 @default.
- W2886600523 cites W2092012609 @default.
- W2886600523 cites W2094733152 @default.
- W2886600523 cites W2096413300 @default.
- W2886600523 cites W2104356883 @default.
- W2886600523 cites W2105291849 @default.
- W2886600523 cites W2109477850 @default.
- W2886600523 cites W2109480888 @default.
- W2886600523 cites W2109977046 @default.
- W2886600523 cites W2127274349 @default.
- W2886600523 cites W2131344889 @default.
- W2886600523 cites W2140936726 @default.
- W2886600523 cites W2151898297 @default.
- W2886600523 cites W2152112546 @default.
- W2886600523 cites W2155431764 @default.
- W2886600523 cites W2161906796 @default.
- W2886600523 cites W2169214521 @default.
- W2886600523 cites W2209395704 @default.
- W2886600523 cites W2513750746 @default.
- W2886600523 cites W2605830903 @default.
- W2886600523 cites W2607215700 @default.
- W2886600523 cites W2716100108 @default.
- W2886600523 cites W2793690257 @default.
- W2886600523 cites W58112070 @default.
- W2886600523 doi "https://doi.org/10.1016/j.virol.2018.08.004" @default.
- W2886600523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30130702" @default.
- W2886600523 hasPublicationYear "2018" @default.
- W2886600523 type Work @default.
- W2886600523 sameAs 2886600523 @default.
- W2886600523 citedByCount "4" @default.
- W2886600523 countsByYear W28866005232020 @default.
- W2886600523 countsByYear W28866005232021 @default.
- W2886600523 crossrefType "journal-article" @default.
- W2886600523 hasAuthorship W2886600523A5032891751 @default.
- W2886600523 hasAuthorship W2886600523A5050852420 @default.
- W2886600523 hasAuthorship W2886600523A5051406306 @default.
- W2886600523 hasConcept C104317684 @default.
- W2886600523 hasConcept C106358424 @default.
- W2886600523 hasConcept C142724271 @default.
- W2886600523 hasConcept C159047783 @default.
- W2886600523 hasConcept C182704531 @default.
- W2886600523 hasConcept C2522874641 @default.
- W2886600523 hasConcept C2776408679 @default.
- W2886600523 hasConcept C2778163477 @default.
- W2886600523 hasConcept C2779134260 @default.
- W2886600523 hasConcept C40692019 @default.
- W2886600523 hasConcept C54355233 @default.
- W2886600523 hasConcept C55493867 @default.
- W2886600523 hasConcept C57089818 @default.
- W2886600523 hasConcept C62746215 @default.
- W2886600523 hasConcept C71924100 @default.
- W2886600523 hasConcept C77957584 @default.
- W2886600523 hasConcept C86803240 @default.
- W2886600523 hasConceptScore W2886600523C104317684 @default.
- W2886600523 hasConceptScore W2886600523C106358424 @default.
- W2886600523 hasConceptScore W2886600523C142724271 @default.
- W2886600523 hasConceptScore W2886600523C159047783 @default.
- W2886600523 hasConceptScore W2886600523C182704531 @default.
- W2886600523 hasConceptScore W2886600523C2522874641 @default.
- W2886600523 hasConceptScore W2886600523C2776408679 @default.
- W2886600523 hasConceptScore W2886600523C2778163477 @default.