FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886643251> ?p ?o ?g. }

• W2886643251 endingPage "3538" @default.
• W2886643251 startingPage "3525" @default.
• W2886643251 abstract "To counteract the lethal acid stress, bacteria explore such strategies as cytoplasmic decarboxylase-catalyzed proton consumption and periplasmic chaperone-assisted protein refolding. Here, we report a periplasmic protease-mediated acid resistance mechanism in Escherichia coli. Deletion of the protease gene degP dramatically decreases the viability of late log or early stationary phase cells against the extreme acid stress (pH 2.3), which can only be minimally rescued by complementary expression of the protease-deficient DegP(S210A) mutant protein. Similarly, DegQ, a homolog of DegP, also contributes to the bacterial acid resistance, but SurA as an important periplasmic chaperone hardly exhibits protection effect. In vitro studies reveal that DegP completely loses its protease activity under acidic condition but is able to partially reactivate upon neutralization. Importantly, we demonstrate the interaction of DegP with typical cellular substrate proteins in cells during acid stress and/or recovery stages by using unnatural amino acid-mediated in vivo photo-crosslinking, as well as the degradation of periplasmic proteins by DegP during recovery after acidic denaturation. These data illustrate the role of DegP in bacterial acid resistance conceivably via degrading those acid-induced misfolded proteins. Our findings, together with earlier reports, suggest a comprehensive acid resistance strategy adopted by bacteria such that in the ATP-deficient extra-cytoplasm, the inevitable misfolded proteins induced by acid stress are refolded by a chaperone (e.g., HdeA/HdeB) and/or cleaved by a protease (e.g., DegP/DegQ) while in the cytoplasm excessive protons are directly consumed or exported." @default.
• W2886643251 created "2018-08-22" @default.
• W2886643251 creator A5003642180 @default.
• W2886643251 creator A5017467540 @default.
• W2886643251 creator A5032066003 @default.
• W2886643251 creator A5032946514 @default.
• W2886643251 creator A5039006501 @default.
• W2886643251 creator A5081867201 @default.
• W2886643251 creator A5091186725 @default.
• W2886643251 date "2018-08-24" @default.
• W2886643251 modified "2023-10-17" @default.
• W2886643251 title "DegP functions as a critical protease for bacterial acid resistance" @default.
• W2886643251 cites W1555789084 @default.
• W2886643251 cites W1649485376 @default.
• W2886643251 cites W1891420776 @default.
• W2886643251 cites W1897988095 @default.
• W2886643251 cites W1970297051 @default.
• W2886643251 cites W1974830640 @default.
• W2886643251 cites W1992681586 @default.
• W2886643251 cites W1999305069 @default.
• W2886643251 cites W2004254961 @default.
• W2886643251 cites W2006061929 @default.
• W2886643251 cites W2010924361 @default.
• W2886643251 cites W2016167342 @default.
• W2886643251 cites W2023131321 @default.
• W2886643251 cites W2043154296 @default.
• W2886643251 cites W2044581495 @default.
• W2886643251 cites W2058173406 @default.
• W2886643251 cites W2066109064 @default.
• W2886643251 cites W2068683917 @default.
• W2886643251 cites W2089283765 @default.
• W2886643251 cites W2092742379 @default.
• W2886643251 cites W2095172074 @default.
• W2886643251 cites W2095449747 @default.
• W2886643251 cites W2108795036 @default.
• W2886643251 cites W2114511757 @default.
• W2886643251 cites W2116222887 @default.
• W2886643251 cites W2117734751 @default.
• W2886643251 cites W2124802836 @default.
• W2886643251 cites W2128744824 @default.
• W2886643251 cites W2129487696 @default.
• W2886643251 cites W2133323026 @default.
• W2886643251 cites W2136936386 @default.
• W2886643251 cites W2137745451 @default.
• W2886643251 cites W2139603922 @default.
• W2886643251 cites W2142898494 @default.
• W2886643251 cites W2143979123 @default.
• W2886643251 cites W2144458042 @default.
• W2886643251 cites W2145153082 @default.
• W2886643251 cites W2145672685 @default.
• W2886643251 cites W2149915307 @default.
• W2886643251 cites W2152434411 @default.
• W2886643251 cites W2154283183 @default.
• W2886643251 cites W2157100014 @default.
• W2886643251 cites W2157777339 @default.
• W2886643251 cites W2161845131 @default.
• W2886643251 cites W2164698747 @default.
• W2886643251 cites W2166168765 @default.
• W2886643251 cites W2167380196 @default.
• W2886643251 cites W2172287485 @default.
• W2886643251 cites W2610187874 @default.
• W2886643251 doi "https://doi.org/10.1111/febs.14627" @default.
• W2886643251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30085413" @default.
• W2886643251 hasPublicationYear "2018" @default.
• W2886643251 type Work @default.
• W2886643251 sameAs 2886643251 @default.
• W2886643251 citedByCount "19" @default.
• W2886643251 countsByYear W28866432512019 @default.
• W2886643251 countsByYear W28866432512020 @default.
• W2886643251 countsByYear W28866432512021 @default.
• W2886643251 countsByYear W28866432512022 @default.
• W2886643251 countsByYear W28866432512023 @default.
• W2886643251 crossrefType "journal-article" @default.
• W2886643251 hasAuthorship W2886643251A5003642180 @default.
• W2886643251 hasAuthorship W2886643251A5017467540 @default.
• W2886643251 hasAuthorship W2886643251A5032066003 @default.
• W2886643251 hasAuthorship W2886643251A5032946514 @default.
• W2886643251 hasAuthorship W2886643251A5039006501 @default.
• W2886643251 hasAuthorship W2886643251A5081867201 @default.
• W2886643251 hasAuthorship W2886643251A5091186725 @default.
• W2886643251 hasBestOaLocation W28866432511 @default.
• W2886643251 hasConcept C104317684 @default.
• W2886643251 hasConcept C142724271 @default.
• W2886643251 hasConcept C143065580 @default.
• W2886643251 hasConcept C181199279 @default.
• W2886643251 hasConcept C190062978 @default.
• W2886643251 hasConcept C201663137 @default.
• W2886643251 hasConcept C204328495 @default.
• W2886643251 hasConcept C2775962898 @default.
• W2886643251 hasConcept C2776714187 @default.
• W2886643251 hasConcept C523546767 @default.
• W2886643251 hasConcept C54355233 @default.
• W2886643251 hasConcept C547475151 @default.
• W2886643251 hasConcept C55493867 @default.
• W2886643251 hasConcept C71924100 @default.
• W2886643251 hasConcept C86803240 @default.
• W2886643251 hasConcept C87190427 @default.
• W2886643251 hasConceptScore W2886643251C104317684 @default.

• next