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- W2886651685 abstract "Objective: It has been shown that glucagon-like peptide-1 (GLP-1) signaling is protective effect in cardiovascular system. Thus, it is important to elucidate the underlying molecular mechanisms to develop a pharmacological treatment. We examined the effect of DPP-4 inhibitor (Alogliptin) and GLP-1 receptor analog (Lixisenatide) on AAA development. Methods: Thirty AAA model rats were divided into 2 groups: a control group (water) and alogliptin group (3 mg/kg/day). Alogliptin administration by gastric gavage was started at 7 days after aneurysm preparation. On day 14, plasma GLP-1 concentrations were measured with an ELISA. Furthermore we investigated the effect of lixisenatide to elucidate the role of GLP-1 signaling on AAA development, 42 rats were divided into 3 groups: a control group (saline), a low-dose group (10 μg/kg/day), and a high-dose group (100 μg/kg/day). Lixisenatide subcutaneous injection was started at 7 days after aneurysm preparation. Reactive oxygen species (ROS) expression in all group..." @default.
- W2886651685 created "2018-08-22" @default.
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- W2886651685 date "2015-05-01" @default.
- W2886651685 modified "2023-09-24" @default.
- W2886651685 title "Abstract 671: Glucagon-like Peptide-1 Inhibits Abdominal Aortic Aneurysm Development" @default.
- W2886651685 hasPublicationYear "2015" @default.
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