Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886665195> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2886665195 endingPage "e0201949" @default.
- W2886665195 startingPage "e0201949" @default.
- W2886665195 abstract "Birch buds (Gemmae Betulae) are widely used in Russian and Chinese traditional medicine mainly as a diuretic and diaphoretic agent but also as an antiseptic, anti-inflammatory and analgesic. Despite the long history of therapeutic use of birch buds in folk medicine, the existing information on their chemical composition and pharmacological effects is insufficient. This circumstance warrants further study of the chemistry and pharmacology of birch buds. The present study was designed to investigate (a) the chemical composition of buds from two species of white birch and (b) the in vitro cytotoxic effect of extracts from these sources on selected tumour cells. Extracts from Betula pubescens Ehrh. and Betula pendula Roth. buds were obtained using three different methods: carbon dioxide supercritical fluid extraction (SFE), washing of exudate covering whole buds, and extraction of milled buds with diethyl ether. The chemical composition of extracts was investigated by GC-MS. Cytotoxicity was determined by MTT assay, and cell proliferation was determined by [3H]thymidine uptake in cancer cells and normal skin fibroblasts. The GC-MS investigation identified a total of 150 substances of different classes. The chemical composition of B. pubescens and B. pendula buds differed, with bud extracts from the former containing a relatively high quantity of sesquiterpenoids and flavonoids, while the main components of extracts from the latter were triterpenoids. The results of the biological assay indicated that birch bud extracts demonstrated time- and concentration-dependent and differential cytotoxicity. The highest cytotoxic activity demonstrated bud exudates and SFE extracts obtained from both Betula species. The rich chemical composition of birch buds suggests the possibility of a wider spectrum of biological activity than previously thought. Birch bud extracts could be a promising source of compounds with cytotoxic activity against various cancers." @default.
- W2886665195 created "2018-08-22" @default.
- W2886665195 creator A5013980021 @default.
- W2886665195 creator A5017936056 @default.
- W2886665195 creator A5078931616 @default.
- W2886665195 date "2018-08-14" @default.
- W2886665195 modified "2023-10-17" @default.
- W2886665195 title "Cytotoxicity of white birch bud extracts: Perspectives for therapy of tumours" @default.
- W2886665195 cites W1976300157 @default.
- W2886665195 cites W1976810457 @default.
- W2886665195 cites W1984704563 @default.
- W2886665195 cites W1989852705 @default.
- W2886665195 cites W1997702573 @default.
- W2886665195 cites W1998111986 @default.
- W2886665195 cites W2007377081 @default.
- W2886665195 cites W2011405860 @default.
- W2886665195 cites W2016134593 @default.
- W2886665195 cites W2031039229 @default.
- W2886665195 cites W2042615004 @default.
- W2886665195 cites W2043881716 @default.
- W2886665195 cites W2050153313 @default.
- W2886665195 cites W2066218141 @default.
- W2886665195 cites W2087951199 @default.
- W2886665195 cites W2105023135 @default.
- W2886665195 cites W2126891371 @default.
- W2886665195 cites W2435076963 @default.
- W2886665195 doi "https://doi.org/10.1371/journal.pone.0201949" @default.
- W2886665195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6091957" @default.
- W2886665195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30106978" @default.
- W2886665195 hasPublicationYear "2018" @default.
- W2886665195 type Work @default.
- W2886665195 sameAs 2886665195 @default.
- W2886665195 citedByCount "14" @default.
- W2886665195 countsByYear W28866651952019 @default.
- W2886665195 countsByYear W28866651952020 @default.
- W2886665195 countsByYear W28866651952021 @default.
- W2886665195 countsByYear W28866651952022 @default.
- W2886665195 countsByYear W28866651952023 @default.
- W2886665195 crossrefType "journal-article" @default.
- W2886665195 hasAuthorship W2886665195A5013980021 @default.
- W2886665195 hasAuthorship W2886665195A5017936056 @default.
- W2886665195 hasAuthorship W2886665195A5078931616 @default.
- W2886665195 hasBestOaLocation W28866651951 @default.
- W2886665195 hasConcept C109316439 @default.
- W2886665195 hasConcept C185592680 @default.
- W2886665195 hasConcept C202751555 @default.
- W2886665195 hasConcept C2777920390 @default.
- W2886665195 hasConcept C2778573061 @default.
- W2886665195 hasConcept C2993942001 @default.
- W2886665195 hasConcept C55493867 @default.
- W2886665195 hasConcept C556039675 @default.
- W2886665195 hasConcept C59822182 @default.
- W2886665195 hasConcept C71924100 @default.
- W2886665195 hasConcept C86803240 @default.
- W2886665195 hasConceptScore W2886665195C109316439 @default.
- W2886665195 hasConceptScore W2886665195C185592680 @default.
- W2886665195 hasConceptScore W2886665195C202751555 @default.
- W2886665195 hasConceptScore W2886665195C2777920390 @default.
- W2886665195 hasConceptScore W2886665195C2778573061 @default.
- W2886665195 hasConceptScore W2886665195C2993942001 @default.
- W2886665195 hasConceptScore W2886665195C55493867 @default.
- W2886665195 hasConceptScore W2886665195C556039675 @default.
- W2886665195 hasConceptScore W2886665195C59822182 @default.
- W2886665195 hasConceptScore W2886665195C71924100 @default.
- W2886665195 hasConceptScore W2886665195C86803240 @default.
- W2886665195 hasFunder F4320323075 @default.
- W2886665195 hasIssue "8" @default.
- W2886665195 hasLocation W28866651951 @default.
- W2886665195 hasLocation W28866651952 @default.
- W2886665195 hasLocation W28866651953 @default.
- W2886665195 hasLocation W28866651954 @default.
- W2886665195 hasLocation W28866651955 @default.
- W2886665195 hasOpenAccess W2886665195 @default.
- W2886665195 hasPrimaryLocation W28866651951 @default.
- W2886665195 hasRelatedWork W1996312970 @default.
- W2886665195 hasRelatedWork W2015482462 @default.
- W2886665195 hasRelatedWork W2018685336 @default.
- W2886665195 hasRelatedWork W2051198198 @default.
- W2886665195 hasRelatedWork W2052958755 @default.
- W2886665195 hasRelatedWork W2604789524 @default.
- W2886665195 hasRelatedWork W33828680 @default.
- W2886665195 hasRelatedWork W4240131276 @default.
- W2886665195 hasRelatedWork W4293106174 @default.
- W2886665195 hasRelatedWork W4307301533 @default.
- W2886665195 hasVolume "13" @default.
- W2886665195 isParatext "false" @default.
- W2886665195 isRetracted "false" @default.
- W2886665195 magId "2886665195" @default.
- W2886665195 workType "article" @default.