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- W2886720703 endingPage "42" @default.
- W2886720703 startingPage "33" @default.
- W2886720703 abstract "Thymosins have been extracted, characterized, and identified from Thymus. The Thymosins are hormones whose therapeuric applications have seen a recent increase. The action of Thymosin α1 is based on the stimulation of the immune response with a large number of results in a variety of pathologies. The absence of a specific receptor prompted us to investigate the direct interaction with membranes, particularly those exposing phosphatidylserine thus contributing to assess the Thymosin α1's pleiotropy.The interaction with membranes has been studied with a number of models indicating that Thymosin α1 interacts preferentially with negative regions of the membrane (SDS mixed with dodecylphosphocholine) or, better, with vesicles of dipalmitoylphosphatidylcholine with exposed phosphatidylserine.The study of the role of the membrane in the mechanism of action of Thymosin α1 indicated that probably the first interaction occurs at the membrane level with recognition of negative surface due to the phosphatidylserine exposure. Upon assuming a conformation, with two helices with a disordered tract in between, it diffuses on the membrane surface by lateral diffusion. Then the interaction with membrane receptor(s) causes a membrane complex to be formed, with an activation of a signalling cascade. This can be considered the basis of its pleiotropy. Differences in structuration mechamism of Thymosin β4 was outlined." @default.
- W2886720703 created "2018-08-22" @default.
- W2886720703 creator A5022448244 @default.
- W2886720703 creator A5061749592 @default.
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- W2886720703 creator A5074639728 @default.
- W2886720703 creator A5077283167 @default.
- W2886720703 creator A5087853913 @default.
- W2886720703 date "2018-05-31" @default.
- W2886720703 modified "2023-09-25" @default.
- W2886720703 title "Potential mechanism of thymosin-α1-membrane interactions leading to pleiotropy: experimental evidence and hypotheses" @default.
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