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• W2886736637 abstract "The bone marrow (BM) consists of multiple, structured micro-environmental entities—the so called niches, which contain hematopoietic cells as well as stromal cells. These niches fulfill a variety of functions, such as control of the hematopoietic stem cell pool, differentiation of hematopoietic cells, and maintenance of immunological memory. However, due to the molecular and cellular complexity and a lack of suitable histological multiplexing methods, the composition of the various BM niches is still elusive. In this study, we apply multiepitope-ligand-cartography (MELC) on bone sections from mice. We combine multiplexed immunofluorescence histology data with various object-based segmentation approaches in order to define irregularly shaped, net-like structures of stromal cells. We confirm MELC as a robust histological method and validate our automated segmentation algorithms using flow cytometry and manual evaluation. By means of MELC multiplexing, we reveal heterogeneous expression of leptin receptor (LpR), BP-1, and VCAM-1 in the stromal network. Moreover, we demonstrate by quantification a preferential contact of B cell subsets as well as of plasma cells to processes of CXCL12-expressing stromal cells, compared with stromal somata. In summary, our approach is suitable for spatial analysis of complex tissue structures." @default.
• W2886736637 created "2018-08-22" @default.
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• W2886736637 date "2018-08-14" @default.
• W2886736637 modified "2023-10-18" @default.
• W2886736637 title "Multiplexed fluorescence microscopy reveals heterogeneity among stromal cells in mouse bone marrow sections" @default.
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• W2886736637 doi "https://doi.org/10.1002/cyto.a.23526" @default.
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