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• W2886744203 abstract "Background Pericytes have been shown to have mesenchymal stromal cell–like properties and play a role in tissue regeneration. The goal of this study was to determine whether the addition of a pericyte sheet to a full-thickness dermal wound would enhance the healing of an acute wound. Methods Human muscle-derived pericytes and human dermal fibroblasts were formed into cell sheets, then applied to full-thickness excisional wounds on the dorsum of nu/nu mice. Histology was performed to evaluate epidermal and dermal reformation, inflammation and fibrosis. In addition, real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was used to determine cytokine response. Results Pericytes were detected in the wounds until day 16 but not fibroblasts. Decrease in wound size was noted in pericyte sheet-treated wounds. Enhanced neo-vascularization and healthy granulation tissue formation were noted in the pericyte-treated wounds. Expression of type I collagen messenger RNA (mRNA) was significantly higher in the fibroblast-treated group, whereas Type III collagen mRNA showed significant increase in the pericyte group at days 3, 6 and 9 compared with the fibroblast and no-cell groups. Trichrome staining revealed thick unorganized collagen fibrils in the fibroblast-treated wounds, whereas pericyte-treated wounds contained thinner and more alligned collagen fibrils. Tumor necrosis factor (TNF)-α mRNA levels were increased in the fibroblast-treated wounds compared with pericyte-treated wounds. Discussion The addition of pericytes may confer beneficial effects to wound healing resulting in reduced recruitment of inflammatory cells and collagen I deposition, potential to enhance wound closure and better collagen alignment promoting stronger tissue." @default.
• W2886744203 created "2018-08-22" @default.
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• W2886744203 date "2018-08-01" @default.
• W2886744203 modified "2023-10-10" @default.
• W2886744203 title "Pericytes reduce inflammation and collagen deposition in acute wounds" @default.
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• W2886744203 doi "https://doi.org/10.1016/j.jcyt.2018.06.011" @default.
• W2886744203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30093323" @default.
• W2886744203 hasPublicationYear "2018" @default.
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