Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886778846> ?p ?o ?g. }
- W2886778846 endingPage "127" @default.
- W2886778846 startingPage "127" @default.
- W2886778846 abstract "Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumulation and thus increase MDR across a variety of cancers. Overcoming MDR is one desired approach to improving the survival rate of patients. To date, a number of modulators have been identified which block the function and/or decrease the expression of ABC transporters, thereby restoring the efficacy of a range of anticancer drugs. However, clinical MDR reversal agents have thus far proven ineffective and/or toxic. The need for new, effective, well-tolerated and nontoxic compounds has led to the development of natural compounds and their derivatives to ameliorate MDR. This review evaluates whether synthetically modifying natural compounds is a viable strategy to generate potent, nontoxic, ABC transporter inhibitors which may potentially reverse MDR." @default.
- W2886778846 created "2018-08-22" @default.
- W2886778846 creator A5007322694 @default.
- W2886778846 creator A5020916384 @default.
- W2886778846 creator A5025929917 @default.
- W2886778846 creator A5037894273 @default.
- W2886778846 creator A5038498358 @default.
- W2886778846 creator A5039239695 @default.
- W2886778846 creator A5075820802 @default.
- W2886778846 creator A5076996795 @default.
- W2886778846 date "2018-08-09" @default.
- W2886778846 modified "2023-10-16" @default.
- W2886778846 title "The Effects of Synthetically Modified Natural Compounds on ABC Transporters" @default.
- W2886778846 cites W1110224792 @default.
- W2886778846 cites W1466549797 @default.
- W2886778846 cites W1567907251 @default.
- W2886778846 cites W1646607682 @default.
- W2886778846 cites W1838547618 @default.
- W2886778846 cites W1908587496 @default.
- W2886778846 cites W1964470226 @default.
- W2886778846 cites W1965799368 @default.
- W2886778846 cites W1967104159 @default.
- W2886778846 cites W1969764664 @default.
- W2886778846 cites W1969795656 @default.
- W2886778846 cites W1970359870 @default.
- W2886778846 cites W1972301936 @default.
- W2886778846 cites W1972733003 @default.
- W2886778846 cites W1986558997 @default.
- W2886778846 cites W1988124545 @default.
- W2886778846 cites W1988300787 @default.
- W2886778846 cites W1990575393 @default.
- W2886778846 cites W1992823317 @default.
- W2886778846 cites W1998583060 @default.
- W2886778846 cites W1999048852 @default.
- W2886778846 cites W1999795186 @default.
- W2886778846 cites W2003323323 @default.
- W2886778846 cites W2004472540 @default.
- W2886778846 cites W2006434892 @default.
- W2886778846 cites W2010112752 @default.
- W2886778846 cites W2012719422 @default.
- W2886778846 cites W2014593961 @default.
- W2886778846 cites W2015085252 @default.
- W2886778846 cites W2015364135 @default.
- W2886778846 cites W2019161486 @default.
- W2886778846 cites W2021550176 @default.
- W2886778846 cites W2028333540 @default.
- W2886778846 cites W2028533496 @default.
- W2886778846 cites W2030810310 @default.
- W2886778846 cites W2031363024 @default.
- W2886778846 cites W2031407900 @default.
- W2886778846 cites W2032945022 @default.
- W2886778846 cites W2033431239 @default.
- W2886778846 cites W2037621239 @default.
- W2886778846 cites W2044898082 @default.
- W2886778846 cites W2046245921 @default.
- W2886778846 cites W2047069988 @default.
- W2886778846 cites W2048047193 @default.
- W2886778846 cites W2050767064 @default.
- W2886778846 cites W2053545020 @default.
- W2886778846 cites W2057009086 @default.
- W2886778846 cites W2065252231 @default.
- W2886778846 cites W2067282464 @default.
- W2886778846 cites W2071025146 @default.
- W2886778846 cites W2072826958 @default.
- W2886778846 cites W2072948376 @default.
- W2886778846 cites W2074525949 @default.
- W2886778846 cites W2074701706 @default.
- W2886778846 cites W2076174476 @default.
- W2886778846 cites W2077647060 @default.
- W2886778846 cites W2078777597 @default.
- W2886778846 cites W2079421040 @default.
- W2886778846 cites W2080745163 @default.
- W2886778846 cites W2081157243 @default.
- W2886778846 cites W2083973731 @default.
- W2886778846 cites W2085076909 @default.
- W2886778846 cites W2086843396 @default.
- W2886778846 cites W2090741417 @default.
- W2886778846 cites W2092296126 @default.
- W2886778846 cites W2094455749 @default.
- W2886778846 cites W2096204304 @default.
- W2886778846 cites W2098671913 @default.
- W2886778846 cites W2100596948 @default.
- W2886778846 cites W2101382252 @default.
- W2886778846 cites W2103037064 @default.
- W2886778846 cites W2103238639 @default.
- W2886778846 cites W2117259973 @default.
- W2886778846 cites W2117640334 @default.
- W2886778846 cites W2119098656 @default.
- W2886778846 cites W2125329951 @default.
- W2886778846 cites W2129397604 @default.
- W2886778846 cites W2136953408 @default.
- W2886778846 cites W2138959604 @default.
- W2886778846 cites W2141116781 @default.
- W2886778846 cites W2149789782 @default.
- W2886778846 cites W2150497755 @default.
- W2886778846 cites W2150824205 @default.
- W2886778846 cites W2160703113 @default.
- W2886778846 cites W2167996410 @default.