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- W2886781520 abstract "Objectives: Wound healing and angiogenesis are impaired in patients with diabetes and peripheral vascular disease. We developed a novel treatment by systemic administration of mesenchymal stem cells (MSC) coated with nanocarrier composed of adhesion molecule -nanoparticle complex (AMNC). AMNC-MSC significantly enhanced wound healing and angiogenesis, in wild type and diabetic mice. AMNC-MSC targeted homing is specific to the injured tissue and superior to BSA (control)-NC coating or uncoated MSC. We now investigate the biosafety profile of the AMNC-MSC. Method: 1x 106 HUVEC were coated with AMNC. Cytotoxicity of AMNC was evaluated by trypan blue. Cell apoptosis was analyzed by flow cytometry using FITC-Annexin-V and propidium iodide. 12-14 week-old C57BL6 mice (N=15) underwent 6mm full thickness dorsal dermal wounding and then assigned to 3 IV treatment groups: (i) 1x 106 AMNC-MSC, (ii) 1x 106 MSC and (iii) equivalent volume saline (No Treatment (NT); (n=5/group). Day 8 post-wounding and treatment, compre..." @default.
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- W2886781520 date "2014-05-01" @default.
- W2886781520 modified "2023-09-23" @default.
- W2886781520 title "Abstract 506: Nanocarrier-Targeted Mesenchymal Stem Cell for Angiogenesis and Wound Healing" @default.
- W2886781520 hasPublicationYear "2014" @default.
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