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- W2886808119 abstract "Abstract Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD + and NADH, using NAD + and NADH as non-canonical initiating nucleotides for transcription initiation. Here, we show that mitochondrial RNAPs (mtRNAPs) cap RNA with NAD + and NADH, and do so more efficiently than nuclear RNAPs. Direct quantitation of NAD + - and NADH-capped RNA demonstrates remarkably high levels of capping in vivo : up to ~60% NAD + and NADH capping of yeast mitochondrial transcripts, and up to ~10% NAD + capping of human mitochondrial transcripts. The capping efficiency is determined by promoter sequence at, and upstream of, the transcription start site and, in yeast and human cells, by intracellular NAD + and NADH levels. Our findings indicate mtRNAPs serve as both sensors and actuators in coupling cellular metabolism to mitochondrial gene expression, sensing NAD + and NADH levels and adjusting transcriptional outputs accordingly." @default.
- W2886808119 created "2018-08-22" @default.
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- W2886808119 date "2018-07-31" @default.
- W2886808119 modified "2023-10-13" @default.
- W2886808119 title "Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD+ and NADH by yeast and human mitochondrial RNA polymerase" @default.
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- W2886808119 doi "https://doi.org/10.1101/381160" @default.
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