Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886838574> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2886838574 abstract "Background—Vitamin E is well known as an antioxidant, and numerous studies suggest that it has a preventive role in atherosclerosis, although the mechanism of action still remains unclear. Methods and Results—The original aim of this study was to establish whether α-tocopherol (the most active form of vitamin E) acts at the earliest events on the cascade of atherosclerosis progression, that of oxidized LDL (oxLDL) uptake and foam-cell formation. We show here that the CD36 scavenger receptor (a specific receptor for oxLDL) is expressed in cultured human aortic smooth muscle cells (SMCs). Treatment of SMCs and HL-60 macrophages with α-tocopherol (50 μmol/L, a physiological concentration) downregulates CD36 expression by reducing its promoter activity. Furthermore, we find that α-tocopherol treatment of SMCs leads to a reduction of oxLDL uptake. Conclusions—This study indicates that CD36 is expressed in cultured human SMCs. In these cells, CD36 transports oxLDL into the cytosol. α-Tocopherol inhibits oxLDL u..." @default.
- W2886838574 created "2018-08-22" @default.
- W2886838574 creator A5013098170 @default.
- W2886838574 creator A5018774383 @default.
- W2886838574 creator A5073364645 @default.
- W2886838574 date "2000-07-04" @default.
- W2886838574 modified "2023-09-26" @default.
- W2886838574 title "Vitamin E Reduces the Uptake of Oxidized LDL by Inhibiting CD36 Scavenger Receptor Expression in Cultured Aortic Smooth Muscle Cells" @default.
- W2886838574 hasPublicationYear "2000" @default.
- W2886838574 type Work @default.
- W2886838574 sameAs 2886838574 @default.
- W2886838574 citedByCount "0" @default.
- W2886838574 crossrefType "journal-article" @default.
- W2886838574 hasAuthorship W2886838574A5013098170 @default.
- W2886838574 hasAuthorship W2886838574A5018774383 @default.
- W2886838574 hasAuthorship W2886838574A5073364645 @default.
- W2886838574 hasConcept C126322002 @default.
- W2886838574 hasConcept C134018914 @default.
- W2886838574 hasConcept C170493617 @default.
- W2886838574 hasConcept C181199279 @default.
- W2886838574 hasConcept C2776940978 @default.
- W2886838574 hasConcept C2777551382 @default.
- W2886838574 hasConcept C2777895019 @default.
- W2886838574 hasConcept C2778004101 @default.
- W2886838574 hasConcept C2778163477 @default.
- W2886838574 hasConcept C2779828298 @default.
- W2886838574 hasConcept C2780072125 @default.
- W2886838574 hasConcept C41443022 @default.
- W2886838574 hasConcept C55493867 @default.
- W2886838574 hasConcept C71924100 @default.
- W2886838574 hasConcept C86803240 @default.
- W2886838574 hasConcept C98539663 @default.
- W2886838574 hasConceptScore W2886838574C126322002 @default.
- W2886838574 hasConceptScore W2886838574C134018914 @default.
- W2886838574 hasConceptScore W2886838574C170493617 @default.
- W2886838574 hasConceptScore W2886838574C181199279 @default.
- W2886838574 hasConceptScore W2886838574C2776940978 @default.
- W2886838574 hasConceptScore W2886838574C2777551382 @default.
- W2886838574 hasConceptScore W2886838574C2777895019 @default.
- W2886838574 hasConceptScore W2886838574C2778004101 @default.
- W2886838574 hasConceptScore W2886838574C2778163477 @default.
- W2886838574 hasConceptScore W2886838574C2779828298 @default.
- W2886838574 hasConceptScore W2886838574C2780072125 @default.
- W2886838574 hasConceptScore W2886838574C41443022 @default.
- W2886838574 hasConceptScore W2886838574C55493867 @default.
- W2886838574 hasConceptScore W2886838574C71924100 @default.
- W2886838574 hasConceptScore W2886838574C86803240 @default.
- W2886838574 hasConceptScore W2886838574C98539663 @default.
- W2886838574 hasLocation W28868385741 @default.
- W2886838574 hasOpenAccess W2886838574 @default.
- W2886838574 hasPrimaryLocation W28868385741 @default.
- W2886838574 hasRelatedWork W1564053001 @default.
- W2886838574 hasRelatedWork W1968157881 @default.
- W2886838574 hasRelatedWork W1992937460 @default.
- W2886838574 hasRelatedWork W1993239840 @default.
- W2886838574 hasRelatedWork W2009433163 @default.
- W2886838574 hasRelatedWork W2013793562 @default.
- W2886838574 hasRelatedWork W2042899507 @default.
- W2886838574 hasRelatedWork W2080215294 @default.
- W2886838574 hasRelatedWork W2093709010 @default.
- W2886838574 hasRelatedWork W2095421021 @default.
- W2886838574 hasRelatedWork W2113848482 @default.
- W2886838574 hasRelatedWork W2114701283 @default.
- W2886838574 hasRelatedWork W2136975647 @default.
- W2886838574 hasRelatedWork W2144854996 @default.
- W2886838574 hasRelatedWork W2163413985 @default.
- W2886838574 hasRelatedWork W2347123634 @default.
- W2886838574 hasRelatedWork W2885964175 @default.
- W2886838574 hasRelatedWork W2962339356 @default.
- W2886838574 hasRelatedWork W2990204773 @default.
- W2886838574 hasRelatedWork W3140228491 @default.
- W2886838574 isParatext "false" @default.
- W2886838574 isRetracted "false" @default.
- W2886838574 magId "2886838574" @default.
- W2886838574 workType "article" @default.