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- W2886925945 abstract "Mitochondrial damage and dysfunction are associated with the aging process, and can be attributed to mutations in both nuclear and mitochondrial genes involved in cellular respiration. Mitochondrial DNA is particularly prone to damage due to its proximity to reactive oxygen species in the mitochondrial matrix. With the current advances in gene therapy studies for both inherited and acquired diseases, mitochondrial dysfunction is an attractive therapeutic target. It could theoretically be corrected through allotropic expression of mitochondrial genes from the nucleus. Inherent to the success of this approach is identification of the way in which nuclear transcripts and proteins destined for the mitochondria are regulated. Recent evidence suggests the involvement of RNA-binding proteins in translation of mitochondrial mRNA. Several of these RNA-binding proteins have been shown to specifically interact with transcripts destined for the respiratory chain, including Pumilio family member Puf3p in yeast and the CLU protein in Drosophila, humans, and other eukaryotes. While numerous mRNA targets of Puf3p and CLU have been experimentally identified, the precise mechanisms of these interactions remain poorly understood. In this project, sets of mRNA transcripts that have been shown to interact with these RNA-binding proteins are screened for sequence motifs that may explain the specificity for mitochondrial transcripts and shed some light on the regulatory adaptations of nuclear-encoded mitochondrial proteins. A 7 nt long linear motif was identified, enriched in the coding region of CLUH target transcripts. Additionally, a motif recognized by human Pumilio proteins PUM1 and PUM2 was found to be enriched in the 3'-UTRs of a few nuclear-encoded mitochondrial transcripts. (Less)" @default.
- W2886925945 created "2018-08-22" @default.
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- W2886925945 date "2018-01-01" @default.
- W2886925945 modified "2023-10-06" @default.
- W2886925945 title "Looking for CLUes and Motifes in mRNA Transcripts" @default.
- W2886925945 hasPublicationYear "2018" @default.
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