FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886947544> ?p ?o ?g. }

• W2886947544 abstract "Inhibition of fibrillation process and disaggregation of mature fibrils using small peptide are the promising remedial strategies to combat neurodegenerative diseases. However, designing peptide-based drugs to target β-sheet-rich amyloid has been a major challenge. The current work describes, for the first time, the amyloid inhibitory potential of the two short peptides (selected on the basis of predisposition of their amino acid residues toward β-sheet formation) using combination of biophysical, imaging methods, and docking approaches. Results showed that peptides employed different mechanisms to inhibit the amyloid fibrillation. Furthermore, they were also effective in blocking the amyloid fibrillation pathway. In contrary to the insulin fibrillar mesh, significantly less fibrillar species appeared in the presence of peptides, as confirmed by transmission electron microscopy. Circular dichroism analysis indicated that although peptides did not stabilize the native state of insulin, they inhibited amyloid aggregation by reducing the formation of β-sheet rich structures. Hemolytic assay revealed the non-hemolytic nature of the species formed when insulin was co-incubated with the peptides. Therefore, despite the inherent potential to form β-sheet structure, these peptides inhibited the amyloid formation and potentially can be used as therapeutics for the treatment of amyloid-related diseases." @default.
• W2886947544 created "2018-08-22" @default.
• W2886947544 creator A5019100292 @default.
• W2886947544 creator A5019444818 @default.
• W2886947544 creator A5039208834 @default.
• W2886947544 creator A5041922445 @default.
• W2886947544 creator A5054382176 @default.
• W2886947544 creator A5057988283 @default.
• W2886947544 creator A5068519638 @default.
• W2886947544 creator A5070905632 @default.
• W2886947544 creator A5074713491 @default.
• W2886947544 creator A5083199032 @default.
• W2886947544 date "2018-08-03" @default.
• W2886947544 modified "2023-10-10" @default.
• W2886947544 title "Elucidating the Inhibitory Potential of Designed Peptides Against Amyloid Fibrillation and Amyloid Associated Cytotoxicity" @default.
• W2886947544 cites W1720271623 @default.
• W2886947544 cites W1967817108 @default.
• W2886947544 cites W1968280815 @default.
• W2886947544 cites W1973897761 @default.
• W2886947544 cites W1974187431 @default.
• W2886947544 cites W1975773796 @default.
• W2886947544 cites W1977956532 @default.
• W2886947544 cites W1991241547 @default.
• W2886947544 cites W1993685623 @default.
• W2886947544 cites W1994307930 @default.
• W2886947544 cites W2001363066 @default.
• W2886947544 cites W2012227432 @default.
• W2886947544 cites W2014571034 @default.
• W2886947544 cites W2014896367 @default.
• W2886947544 cites W2020318455 @default.
• W2886947544 cites W2025464379 @default.
• W2886947544 cites W2028868321 @default.
• W2886947544 cites W2036987252 @default.
• W2886947544 cites W2040824780 @default.
• W2886947544 cites W2053893413 @default.
• W2886947544 cites W2057939921 @default.
• W2886947544 cites W2068202960 @default.
• W2886947544 cites W2068834560 @default.
• W2886947544 cites W2070050768 @default.
• W2886947544 cites W2075452719 @default.
• W2886947544 cites W2085346125 @default.
• W2886947544 cites W2091009731 @default.
• W2886947544 cites W2105668062 @default.
• W2886947544 cites W2135861788 @default.
• W2886947544 cites W2138531756 @default.
• W2886947544 cites W2141488428 @default.
• W2886947544 cites W2164818290 @default.
• W2886947544 cites W2165186407 @default.
• W2886947544 cites W2169956010 @default.
• W2886947544 cites W2218148126 @default.
• W2886947544 cites W2219879224 @default.
• W2886947544 cites W2228906515 @default.
• W2886947544 cites W2279327176 @default.
• W2886947544 cites W2328301052 @default.
• W2886947544 cites W2401045631 @default.
• W2886947544 cites W2401053207 @default.
• W2886947544 cites W2412921526 @default.
• W2886947544 cites W2433895531 @default.
• W2886947544 cites W2493891030 @default.
• W2886947544 cites W2539371511 @default.
• W2886947544 cites W2546673924 @default.
• W2886947544 cites W2557320814 @default.
• W2886947544 cites W2591764381 @default.
• W2886947544 cites W2607334516 @default.
• W2886947544 cites W2739980134 @default.
• W2886947544 cites W2789819212 @default.
• W2886947544 cites W834156084 @default.
• W2886947544 doi "https://doi.org/10.3389/fchem.2018.00311" @default.
• W2886947544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6085999" @default.
• W2886947544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30123793" @default.
• W2886947544 hasPublicationYear "2018" @default.
• W2886947544 type Work @default.
• W2886947544 sameAs 2886947544 @default.
• W2886947544 citedByCount "37" @default.
• W2886947544 countsByYear W28869475442018 @default.
• W2886947544 countsByYear W28869475442019 @default.
• W2886947544 countsByYear W28869475442020 @default.
• W2886947544 countsByYear W28869475442021 @default.
• W2886947544 countsByYear W28869475442022 @default.
• W2886947544 countsByYear W28869475442023 @default.
• W2886947544 crossrefType "journal-article" @default.
• W2886947544 hasAuthorship W2886947544A5019100292 @default.
• W2886947544 hasAuthorship W2886947544A5019444818 @default.
• W2886947544 hasAuthorship W2886947544A5039208834 @default.
• W2886947544 hasAuthorship W2886947544A5041922445 @default.
• W2886947544 hasAuthorship W2886947544A5054382176 @default.
• W2886947544 hasAuthorship W2886947544A5057988283 @default.
• W2886947544 hasAuthorship W2886947544A5068519638 @default.
• W2886947544 hasAuthorship W2886947544A5070905632 @default.
• W2886947544 hasAuthorship W2886947544A5074713491 @default.
• W2886947544 hasAuthorship W2886947544A5083199032 @default.
• W2886947544 hasBestOaLocation W28869475441 @default.
• W2886947544 hasConcept C109316439 @default.
• W2886947544 hasConcept C12554922 @default.
• W2886947544 hasConcept C126322002 @default.
• W2886947544 hasConcept C133571119 @default.
• W2886947544 hasConcept C177907266 @default.
• W2886947544 hasConcept C179104552 @default.
• W2886947544 hasConcept C185592680 @default.
• W2886947544 hasConcept C202751555 @default.

• next