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- W2886961790 abstract "Abstract The incidence of myocardial infarction is significantly higher in hypertensive patients with increased plasma concentration of angiotensin (Ang) II. Ang II was shown to bind to LDL in vitro, and in the present study we showed its binding to LDL in vivo. Ang II (10−7 mol/L) was incubated with LDL for 3 hours at 37°C, followed by reseparation of the modified lipoprotein (Ang II–LDL) and its incubation with J-774 A.1 macrophages. Binding of Ang II to LDL significantly increased the lipoprotein protein degradation (by 25%) and its cell association (by 75%) compared with nontreated LDL. Unlike Ang II–LDL, both Ang I–LDL and Ang III–LDL were taken up by macrophages similar to native LDL. The lipid composition and size of Ang II–LDL were similar to those of native LDL, and it was not aggregated. Ang II–LDL was not oxidized, as the contents of malondialdehyde and peroxides were not different from those found in native LDL. On heparin-Sepharose column chromatography, Ang II–LDL was eluted in the void volu..." @default.
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- W2886961790 date "1996-01-01" @default.
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- W2886961790 title "Angiotensin II–Modified LDL Is Taken Up by Macrophages Via the Scavenger Receptor, Leading to Cellular Cholesterol Accumulation" @default.
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