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- W2886972271 abstract "Objective—Growth factors may play a permissive role in atherosclerosis initiation and progression, in part via their promotion of vascular smooth muscle cell (VSMC) accumulation in plaques. However, unstable human plaques often have a relative paucity of VSMC, which has been suggested to contribute to plaque rupture and erosion and to clinical events. Insulin-like growth factor-1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that is a mitogen for VSMC, but when infused into Apoe−/− mice it paradoxically reduces atherosclerosis burden. Methods and Results—To determine the effect of stimulation of VSMC growth on atherosclerotic plaque development and to understand mechanisms of IGF-1’s atheroprotective effect, we assessed atherosclerotic plaques in mice overexpressing IGF-1 in smooth muscle cells (SMC) under the control of the α-smooth muscle actin promoter, after backcrossing to the Apoe−/− background (SMP8/Apoe−/−). Compared with Apoe−/− mice, these SMP8/Apoe−/− mice developed a comparable..." @default.
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- W2886972271 date "2010-10-01" @default.
- W2886972271 modified "2023-09-26" @default.
- W2886972271 title "Smooth Muscle Cell–Specific Insulin-Like Growth Factor-1 Overexpression in Apoe−/− Mice Does Not Alter Atherosclerotic Plaque Burden but Increases Features of Plaque Stability" @default.
- W2886972271 hasPublicationYear "2010" @default.
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