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- W2886977703 abstract "Alangium longiflorum is currently in extinction crisis, which will likely severely hamper further phytochemical investigation of this plant species from new collections. A crude extract of leaves of A. longiflorum (N33539), collected for the U.S. National Cancer Institute in 1989, showed potent cancer cell line antiproliferative activity. A phytochemical study resulted in the isolation of 17 secondary metabolites, including two new tetrahydroisoquinoline alkaloids, 8-hydroxytubulosine (1) and 2′-O-trans-sinapoylisoalangiside (2), as well as a new sinapolyloxylupene derivative (3). Using in-house assays and NCI-60 panel screening, compound 1 displayed broad-spectrum inhibitory activity at submicromolar levels against most tested tumor cell lines, except for drug-transporter-overexpressing cells. Compound 1 caused accumulation of sub-G1 cells with no effect on cell cycle progression, suggesting that this substance is an apoptosis inducer." @default.
- W2886977703 created "2018-08-22" @default.
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- W2886977703 date "2018-08-14" @default.
- W2886977703 modified "2023-10-03" @default.
- W2886977703 title "Antiproliferative Alkaloids from <i>Alangium longiflorum</i>, an Endangered Tropical Plant Species" @default.
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- W2886977703 doi "https://doi.org/10.1021/acs.jnatprod.8b00411" @default.
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