Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886979595> ?p ?o ?g. }
- W2886979595 endingPage "72" @default.
- W2886979595 startingPage "72" @default.
- W2886979595 abstract "Feline oral squamous cell carcinoma (OSCC) is a highly invasive form of cancer in cats. In human OSCC, cluster of differentiation 147 (CD147) contributes to inflammation and tumor invasiveness. CD147 is a potential therapeutic target, but the expression of CD147 in feline OSCC has not been examined. Immunohistochemistry was used to determine if cyclooxygenase 2 (COX-2) and CD147 expression in feline OSCC biopsies was coordinated. Tumor cells were more likely to express COX-2 (22/43 cases or 51%) compared to stroma (8/43 or 19%) and adjacent oral epithelium (9/31 cases or 29%) (p < 0.05). CD147 was also more likely to occur in tumor cells compared to stroma and adjacent mucosa, with 21/43 (49%) of cases having >50% tumor cells with mild or moderate CD147 expression, compared to 9/28 (32%) in adjacent epithelium and only 5/43 (12%) in adjacent stroma (p < 0.05). In feline OSCC cell lines (SCCF1, SCCF2, and SCCF3), CD147 gene expression was more consistently expressed compared to COX-2, which was 60-fold higher in SCCF2 cells compared to SCCF1 cells (p < 0.05). CD147 expression did not correlate with COX-2 expression and prostaglandin E2 (PGE2) secretion, indicating that they may be independently regulated. CD147 potentially represents a novel therapeutic target for the treatment of feline OSCC and further study of CD147 is warranted." @default.
- W2886979595 created "2018-08-22" @default.
- W2886979595 creator A5002560234 @default.
- W2886979595 creator A5017453046 @default.
- W2886979595 creator A5025877796 @default.
- W2886979595 creator A5035821309 @default.
- W2886979595 creator A5049477911 @default.
- W2886979595 creator A5050970273 @default.
- W2886979595 creator A5085390138 @default.
- W2886979595 date "2018-08-13" @default.
- W2886979595 modified "2023-10-05" @default.
- W2886979595 title "CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma" @default.
- W2886979595 cites W106940228 @default.
- W2886979595 cites W1496109623 @default.
- W2886979595 cites W1919861831 @default.
- W2886979595 cites W1974451038 @default.
- W2886979595 cites W1975113490 @default.
- W2886979595 cites W1980130680 @default.
- W2886979595 cites W1992885568 @default.
- W2886979595 cites W2013483651 @default.
- W2886979595 cites W2028636893 @default.
- W2886979595 cites W2031602267 @default.
- W2886979595 cites W2033549746 @default.
- W2886979595 cites W2038300246 @default.
- W2886979595 cites W2044110000 @default.
- W2886979595 cites W2044147210 @default.
- W2886979595 cites W2047071374 @default.
- W2886979595 cites W2050224943 @default.
- W2886979595 cites W2056638334 @default.
- W2886979595 cites W2058335617 @default.
- W2886979595 cites W2060669952 @default.
- W2886979595 cites W2069107968 @default.
- W2886979595 cites W2086547274 @default.
- W2886979595 cites W2092222844 @default.
- W2886979595 cites W2093492520 @default.
- W2886979595 cites W2097086662 @default.
- W2886979595 cites W2101600093 @default.
- W2886979595 cites W2103960152 @default.
- W2886979595 cites W2109819319 @default.
- W2886979595 cites W2115937906 @default.
- W2886979595 cites W2117894249 @default.
- W2886979595 cites W2121167265 @default.
- W2886979595 cites W2121968614 @default.
- W2886979595 cites W2123016342 @default.
- W2886979595 cites W2123687363 @default.
- W2886979595 cites W2124548256 @default.
- W2886979595 cites W2124920630 @default.
- W2886979595 cites W2130507785 @default.
- W2886979595 cites W2136789423 @default.
- W2886979595 cites W2139199726 @default.
- W2886979595 cites W2144584998 @default.
- W2886979595 cites W2155391932 @default.
- W2886979595 cites W2162582022 @default.
- W2886979595 cites W2164687062 @default.
- W2886979595 cites W2166502910 @default.
- W2886979595 cites W2183258268 @default.
- W2886979595 cites W2185701329 @default.
- W2886979595 cites W2332292914 @default.
- W2886979595 cites W2514207398 @default.
- W2886979595 cites W2553409263 @default.
- W2886979595 cites W2569044346 @default.
- W2886979595 cites W2745520900 @default.
- W2886979595 cites W938503556 @default.
- W2886979595 doi "https://doi.org/10.3390/vetsci5030072" @default.
- W2886979595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6163611" @default.
- W2886979595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30104530" @default.
- W2886979595 hasPublicationYear "2018" @default.
- W2886979595 type Work @default.
- W2886979595 sameAs 2886979595 @default.
- W2886979595 citedByCount "8" @default.
- W2886979595 countsByYear W28869795952019 @default.
- W2886979595 countsByYear W28869795952020 @default.
- W2886979595 countsByYear W28869795952021 @default.
- W2886979595 countsByYear W28869795952023 @default.
- W2886979595 crossrefType "journal-article" @default.
- W2886979595 hasAuthorship W2886979595A5002560234 @default.
- W2886979595 hasAuthorship W2886979595A5017453046 @default.
- W2886979595 hasAuthorship W2886979595A5025877796 @default.
- W2886979595 hasAuthorship W2886979595A5035821309 @default.
- W2886979595 hasAuthorship W2886979595A5049477911 @default.
- W2886979595 hasAuthorship W2886979595A5050970273 @default.
- W2886979595 hasAuthorship W2886979595A5085390138 @default.
- W2886979595 hasBestOaLocation W28869795951 @default.
- W2886979595 hasConcept C121608353 @default.
- W2886979595 hasConcept C126322002 @default.
- W2886979595 hasConcept C142724271 @default.
- W2886979595 hasConcept C1491633281 @default.
- W2886979595 hasConcept C181199279 @default.
- W2886979595 hasConcept C204232928 @default.
- W2886979595 hasConcept C2777956040 @default.
- W2886979595 hasConcept C2779689624 @default.
- W2886979595 hasConcept C2779904517 @default.
- W2886979595 hasConcept C502942594 @default.
- W2886979595 hasConcept C52124034 @default.
- W2886979595 hasConcept C529295009 @default.
- W2886979595 hasConcept C54355233 @default.
- W2886979595 hasConcept C55493867 @default.
- W2886979595 hasConcept C71924100 @default.