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- W2886986426 abstract "Background and Purpose—The lipid peroxidation inhibitor U-101033E was examined for effects on cerebral blood flow (CBF), cortical tissue hemoglobin oxygen saturation (HbSo2), and neuronal damage. Methods—Fifteen minutes of global cerebral ischemia was induced by two-vessel occlusion and hypobaric hypotension. Wistar rats (n=25) were randomized to receive vehicle (n=9) or 40 mg/kg U-101033E (n=9) intraperitoneally during 2 hours of reperfusion. A sham group (n=7) had neither ischemia nor therapy. Histology was evaluated 7 days after ischemia. Results—During late hyperperfusion (at 17 minutes), vehicle-treated animals had a higher (P=0.044) cortical tissue HbSo2 (72.0±1.4%) than did U-101033E–treated animals (65.8±2.5%). Neuronal counts in the superficial cortex layer found after 7 days correlated negatively with rCBF (r=−0.76; P<0.001) or cortical tissue HbSo2 (r=−0.56; P=0.028) assessed during the late hyperperfusion phase. U-101033E reduced neuronal damage in hippocampal CA1 from 64.3±9.2% to 31.2±8.4% (..." @default.
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- W2886986426 date "1998-06-01" @default.
- W2886986426 modified "2023-09-23" @default.
- W2886986426 title "Postischemic Application of Lipid Peroxidation Inhibitor U-101033E Reduces Neuronal Damage After Global Cerebral Ischemia in Rats" @default.
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