FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887005195> ?p ?o ?g. }

• W2887005195 endingPage "1412" @default.
• W2887005195 startingPage "1407" @default.
• W2887005195 abstract "Hematopoietic stem cell transplantation often involves the cryopreservation of stem cell products. Currently, the standard cryoprotective agent (CPA) is dimethyl sulfoxide (DMSO), which is known to cause concentration-related toxicity and side effects when administered to patients. Based on promising in vitro data from our previous study using pentaisomaltose (a 1 kDa subfraction of Dextran 1) as an alternative to DMSO for cryopreservation of hematopoietic progenitor cells (HPCs) from apheresis products, we proceeded to a preclinical model and compared the two CPAs with respect to engraftment of human hematopoietic stem and progenitor cells (HSPCs) in the immunodeficient NSG mouse model. Human HPCs from apheresis products were cryopreserved with either pentaisomaltose or DMSO, and the following outcomes were measured: (1) the post-thaw recovery of cryopreserved cells and clonogenic potential of CD34 + cells and (2) hematopoietic engraftment in NSG mice. We found that recovery and colony-forming cells data were comparable between pentaisomaltose and DMSO. The engraftment data revealed comparable human CD45 + levels in peripheral blood at 8 weeks and bone marrow at 16 weeks post transplantation. Additionally, the frequencies of CD34 + CD38 low/negative and myeloid/lymphoid cells in the bone marrow were comparable. We here demonstrated that long-term engrafting HSPCs were well preserved in pentaisomaltose and comparable to cells cryopreserved with DMSO. Although a clinical trial is necessary to translate these results into human use, the present data represent an important step toward the replacement of DMSO with a non-toxic alternative." @default.
• W2887005195 created "2018-08-22" @default.
• W2887005195 creator A5005834903 @default.
• W2887005195 creator A5006179863 @default.
• W2887005195 creator A5021007198 @default.
• W2887005195 creator A5022512770 @default.
• W2887005195 creator A5032476205 @default.
• W2887005195 creator A5033792374 @default.
• W2887005195 creator A5044599059 @default.
• W2887005195 creator A5051799158 @default.
• W2887005195 creator A5059822405 @default.
• W2887005195 creator A5061950161 @default.
• W2887005195 date "2018-07-30" @default.
• W2887005195 modified "2023-10-14" @default.
• W2887005195 title "Pentaisomaltose, an Alternative to DMSO. Engraftment of Cryopreserved Human CD34⁺ Cells in Immunodeficient NSG Mice" @default.
• W2887005195 cites W1964452183 @default.
• W2887005195 cites W1965972575 @default.
• W2887005195 cites W1968885762 @default.
• W2887005195 cites W1995032020 @default.
• W2887005195 cites W2013935857 @default.
• W2887005195 cites W2014403060 @default.
• W2887005195 cites W2020529579 @default.
• W2887005195 cites W2026159178 @default.
• W2887005195 cites W2029190023 @default.
• W2887005195 cites W2052696704 @default.
• W2887005195 cites W2062706877 @default.
• W2887005195 cites W2064106835 @default.
• W2887005195 cites W2066137089 @default.
• W2887005195 cites W2081861399 @default.
• W2887005195 cites W2138060959 @default.
• W2887005195 cites W2166045197 @default.
• W2887005195 cites W2300857475 @default.
• W2887005195 cites W2469055990 @default.
• W2887005195 doi "https://doi.org/10.1177/0963689718786226" @default.
• W2887005195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168988" @default.
• W2887005195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30056762" @default.
• W2887005195 hasPublicationYear "2018" @default.
• W2887005195 type Work @default.
• W2887005195 sameAs 2887005195 @default.
• W2887005195 citedByCount "11" @default.
• W2887005195 countsByYear W28870051952020 @default.
• W2887005195 countsByYear W28870051952021 @default.
• W2887005195 countsByYear W28870051952022 @default.
• W2887005195 countsByYear W28870051952023 @default.
• W2887005195 crossrefType "journal-article" @default.
• W2887005195 hasAuthorship W2887005195A5005834903 @default.
• W2887005195 hasAuthorship W2887005195A5006179863 @default.
• W2887005195 hasAuthorship W2887005195A5021007198 @default.
• W2887005195 hasAuthorship W2887005195A5022512770 @default.
• W2887005195 hasAuthorship W2887005195A5032476205 @default.
• W2887005195 hasAuthorship W2887005195A5033792374 @default.
• W2887005195 hasAuthorship W2887005195A5044599059 @default.
• W2887005195 hasAuthorship W2887005195A5051799158 @default.
• W2887005195 hasAuthorship W2887005195A5059822405 @default.
• W2887005195 hasAuthorship W2887005195A5061950161 @default.
• W2887005195 hasBestOaLocation W28870051951 @default.
• W2887005195 hasConcept C10205521 @default.
• W2887005195 hasConcept C109159458 @default.
• W2887005195 hasConcept C117262875 @default.
• W2887005195 hasConcept C126322002 @default.
• W2887005195 hasConcept C159912055 @default.
• W2887005195 hasConcept C16685009 @default.
• W2887005195 hasConcept C178790620 @default.
• W2887005195 hasConcept C179933525 @default.
• W2887005195 hasConcept C185592680 @default.
• W2887005195 hasConcept C196843134 @default.
• W2887005195 hasConcept C201750760 @default.
• W2887005195 hasConcept C202751555 @default.
• W2887005195 hasConcept C203014093 @default.
• W2887005195 hasConcept C2776738589 @default.
• W2887005195 hasConcept C2778452553 @default.
• W2887005195 hasConcept C2779282312 @default.
• W2887005195 hasConcept C2780007613 @default.
• W2887005195 hasConcept C28328180 @default.
• W2887005195 hasConcept C2911091166 @default.
• W2887005195 hasConcept C502942594 @default.
• W2887005195 hasConcept C55493867 @default.
• W2887005195 hasConcept C71924100 @default.
• W2887005195 hasConcept C86803240 @default.
• W2887005195 hasConcept C89560881 @default.
• W2887005195 hasConcept C95444343 @default.
• W2887005195 hasConceptScore W2887005195C10205521 @default.
• W2887005195 hasConceptScore W2887005195C109159458 @default.
• W2887005195 hasConceptScore W2887005195C117262875 @default.
• W2887005195 hasConceptScore W2887005195C126322002 @default.
• W2887005195 hasConceptScore W2887005195C159912055 @default.
• W2887005195 hasConceptScore W2887005195C16685009 @default.
• W2887005195 hasConceptScore W2887005195C178790620 @default.
• W2887005195 hasConceptScore W2887005195C179933525 @default.
• W2887005195 hasConceptScore W2887005195C185592680 @default.
• W2887005195 hasConceptScore W2887005195C196843134 @default.
• W2887005195 hasConceptScore W2887005195C201750760 @default.
• W2887005195 hasConceptScore W2887005195C202751555 @default.
• W2887005195 hasConceptScore W2887005195C203014093 @default.
• W2887005195 hasConceptScore W2887005195C2776738589 @default.
• W2887005195 hasConceptScore W2887005195C2778452553 @default.
• W2887005195 hasConceptScore W2887005195C2779282312 @default.
• W2887005195 hasConceptScore W2887005195C2780007613 @default.

• next