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• W2887014067 abstract "Significance During neural development, growing axons navigate over long distances to reach their targets. A critical step in this process is the regulation of its surface receptors on the axon’s growth cone in response to environmental cues. We focus on how the UNC-5 receptor in Ca enorhabditis elegans motor axons is regulated during axon repulsion. By combining C. elegans genetics, biochemistry, and imaging, we found that MAX-1 SUMOylation and AP-3 complex have significant roles in UNC-5–mediated axon repulsion. Our findings reveal how SUMOylation and AP-3–mediated trafficking and degradation interact to help the growing axon find its final target." @default.
• W2887014067 created "2018-08-22" @default.
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• W2887014067 date "2018-08-13" @default.
• W2887014067 modified "2023-09-25" @default.
• W2887014067 title "Regulation of axon repulsion by MAX-1 SUMOylation and AP-3" @default.
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• W2887014067 doi "https://doi.org/10.1073/pnas.1804373115" @default.
• W2887014067 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6126772" @default.
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