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- W2887016648 abstract "Proteomics, metabolomics, and transcriptomics generate comprehensive data sets, and current biocomputational capabilities allow their efficient integration for systems biology analysis. Published multiomics studies cover methodological advances as well as applications to biological questions. However, few studies have focused on the development of a high-throughput, unified sample preparation approach to complement high-throughput omic analytics. This report details the automation, benchmarking, and application of a strategy for transcriptomic, proteomic, and metabolomic analyses from a common sample. The approach, sample preparation for multi-omics technologies (SPOT), provides equivalent performance to typical individual omic preparation methods but greatly enhances throughput and minimizes the resources required for multiomic experiments. SPOT was applied to a multiomics time course experiment for zinc-treated HL-60 cells. The data reveal Zn effects on NRF2 antioxidant and NFkappaB signaling. High-throughput approaches such as these are critical for the acquisition of temporally resolved, multicondition, large multiomic data sets such as those necessary to assess complex clinical and biological concerns. Ultimately, this type of approach will provide an expanded understanding of challenging scientific questions across many fields." @default.
- W2887016648 created "2018-08-22" @default.
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- W2887016648 date "2018-08-16" @default.
- W2887016648 modified "2023-10-16" @default.
- W2887016648 title "An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis" @default.
- W2887016648 cites W1143127356 @default.
- W2887016648 cites W1493209013 @default.
- W2887016648 cites W1517765895 @default.
- W2887016648 cites W1520187505 @default.
- W2887016648 cites W1941186790 @default.
- W2887016648 cites W1965771646 @default.
- W2887016648 cites W1968567748 @default.
- W2887016648 cites W1976420445 @default.
- W2887016648 cites W1981385227 @default.
- W2887016648 cites W1981912182 @default.
- W2887016648 cites W1993026417 @default.
- W2887016648 cites W1998142996 @default.
- W2887016648 cites W1999517476 @default.
- W2887016648 cites W2002132602 @default.
- W2887016648 cites W2006139079 @default.
- W2887016648 cites W2007752577 @default.
- W2887016648 cites W2015392958 @default.
- W2887016648 cites W2016899606 @default.
- W2887016648 cites W2017458586 @default.
- W2887016648 cites W2018045523 @default.
- W2887016648 cites W2025944550 @default.
- W2887016648 cites W2026088200 @default.
- W2887016648 cites W2031189531 @default.
- W2887016648 cites W2034252508 @default.
- W2887016648 cites W2052085642 @default.
- W2887016648 cites W2055150513 @default.
- W2887016648 cites W2056402897 @default.
- W2887016648 cites W2060811342 @default.
- W2887016648 cites W2066739566 @default.
- W2887016648 cites W2072329234 @default.
- W2887016648 cites W2073509937 @default.
- W2887016648 cites W2079238340 @default.
- W2887016648 cites W2081047481 @default.
- W2887016648 cites W2082836122 @default.
- W2887016648 cites W2089034956 @default.
- W2887016648 cites W2091474030 @default.
- W2887016648 cites W2091497745 @default.
- W2887016648 cites W2095293504 @default.
- W2887016648 cites W2096571675 @default.
- W2887016648 cites W2106859372 @default.
- W2887016648 cites W2116041602 @default.
- W2887016648 cites W2120341844 @default.
- W2887016648 cites W212793913 @default.
- W2887016648 cites W2135581618 @default.
- W2887016648 cites W2140816250 @default.
- W2887016648 cites W2144944458 @default.
- W2887016648 cites W2145156860 @default.
- W2887016648 cites W2151936673 @default.
- W2887016648 cites W2152983548 @default.
- W2887016648 cites W2156658768 @default.
- W2887016648 cites W2159675211 @default.
- W2887016648 cites W2176125616 @default.
- W2887016648 cites W2209651181 @default.
- W2887016648 cites W2260701429 @default.
- W2887016648 cites W2275236249 @default.
- W2887016648 cites W2291477018 @default.
- W2887016648 cites W2322251288 @default.
- W2887016648 cites W2335650918 @default.
- W2887016648 cites W2391375401 @default.
- W2887016648 cites W2406571591 @default.
- W2887016648 cites W2461534763 @default.
- W2887016648 cites W2509618163 @default.
- W2887016648 cites W2537132940 @default.
- W2887016648 cites W2578182640 @default.
- W2887016648 cites W2587514660 @default.
- W2887016648 cites W2591992124 @default.
- W2887016648 cites W2602928966 @default.
- W2887016648 cites W2603756957 @default.
- W2887016648 cites W2613123103 @default.
- W2887016648 cites W2617961063 @default.
- W2887016648 cites W2621084800 @default.
- W2887016648 cites W2624135745 @default.
- W2887016648 cites W2741302852 @default.
- W2887016648 cites W2746059636 @default.
- W2887016648 cites W2750367950 @default.
- W2887016648 cites W94482989 @default.
- W2887016648 doi "https://doi.org/10.1021/acs.jproteome.8b00302" @default.
- W2887016648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6469931" @default.