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- W2887018897 abstract "Vascular cell adhesion molecule (VCAM)-1 plays a dominant role in the initiation of atherosclerosis. Our group has recently reported that the DNA-dependent protein kinase (DNA-PK) regulates TNF-induced expression of VCAM-1 in glioblastoma cells via phosphorylation of p50NF-kppaB at serine-20. Such modification is crucial for the interaction of the transcription factor with p65NF-kappa B and VCAM-1 gene promoter occupancy. In this study, we examined the role of DNA-PK in VCAM-1 expression in vascular cells and the mechanism by which TNF-kappa activates the kinase. DNA-PK is required for TNF-induced VCAM-1 expression in human vein (HUVEC) and aortic (HAEC) endothelial cells. Inhibition of DNA-PK kinase activity blocked p50NF-kappa B phosphorylation at serine-20 using newly-generated antibodies targeting the phosphorylated form of the protein. Inhibition of DNA-PK markedly reduced monocyte adhesion to TNF-stimulated endothelial cells strongly suggesting a potential involvement in atherosclerosis. Indeed, pho..." @default.
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- W2887018897 date "2012-11-20" @default.
- W2887018897 modified "2023-09-25" @default.
- W2887018897 title "Abstract 13252: DNA-Dependent Protein Kinase (DNA-PK) Regulates TNF-Induced VCAM-1 Expression Independently of its Function in DNA Repair: A Novel Role of DNA-PK and its Involvement in Athrogenesis" @default.
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