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- W2887023495 abstract "Carotenoids, including β-carotene, are commercially valuable compounds, and their production by engineered Saccharomyces cerevisiae is a promising strategy for their industrial production. Here, to improve β-carotene productivity in engineered S. cerevisiae, a cocktail δ-integration strategy, which involves simultaneous integration of various multi-copy genes, followed by selection of desirable transformants, was applied for modulation of β-carotene production-related genes expression. The engineered strain, YPH499/Mo3Crt79, was constructed by three repeated rounds of cocktail δ-integration using CrtE, CrtYB, and CrtI derived from the yeast, Xanthophyllomyces dendrorhous. The recombinant strain produced 7.3 mg/L of carotenoids in 48 h and 52.3 mg/L of β-carotene in 96 h, which were greater values than those achieved by CrtE, CrtYB, and CrtI co-overexpressing strains. Therefore, repeated cocktail δ-integration was effective in improving carotenoid productivity in S. cerevisiae and could be a promising technique for constructing metabolically engineered S. cerevisiae capable of producing bio-based chemicals." @default.
- W2887023495 created "2018-08-22" @default.
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- W2887023495 date "2018-11-01" @default.
- W2887023495 modified "2023-10-18" @default.
- W2887023495 title "Modulation of gene expression by cocktail δ-integration to improve carotenoid production in Saccharomyces cerevisiae" @default.
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- W2887023495 doi "https://doi.org/10.1016/j.biortech.2018.08.044" @default.
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