FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887101932> ?p ?o ?g. }

• W2887101932 endingPage "962" @default.
• W2887101932 startingPage "953" @default.
• W2887101932 abstract "Aims Molecular targeted therapy against EGFR kinase domain mutations has been successfully established for lung cancer. These mutations have now also been reported in head and neck tumours, particularly in inverted sinonasal papillomas ( ISP s). The aim of this study was to clarify the spectrum of EGFR mutations in head and neck squamous cell carcinomas and papillomas. Methods and results We examined EGFR mutations in 288 head and neck squamous cell carcinomas and 58 head and neck papillomas or polyps. EGFR mutations were detected in 24 (30%) of 80 sinonasal squamous cell carcinomas ( SNSCC s) and in 19 (90%) of 21 ISP s. Notably, 15 (88%) of 17 SNSCC s that developed along with ISP s harboured EGFR mutations in both components, whereas EGFR mutations were detected in nine (14%) of 63 SNSCC s without any papilloma component. Analysis to detect other known driver oncogene mutations – KRAS , BRAF and HER 2 – was also performed; none of these mutations was detected in SNSCC s. The other 208 non‐sinonasal carcinomas and 37 non‐ ISP head and neck papillomas or polyps did not harbour EGFR mutations. Conclusions Taken together with the specific involvement of EGFR mutations in ISP , a molecular benign lesion trail suggests that 26 (33%) of 80 SNSCC s developed in association with an ISP . SNSCC s with EGFR mutations may be biologically distinct among head and neck cancers." @default.
• W2887101932 created "2018-08-22" @default.
• W2887101932 creator A5011939936 @default.
• W2887101932 creator A5032578932 @default.
• W2887101932 creator A5041410809 @default.
• W2887101932 creator A5060912740 @default.
• W2887101932 creator A5065196329 @default.
• W2887101932 date "2018-10-23" @default.
• W2887101932 modified "2023-10-16" @default.
• W2887101932 title "Sinonasal squamous cell carcinoma and <i>EGFR</i> mutations: a molecular footprint of a benign lesion" @default.
• W2887101932 cites W1607503992 @default.
• W2887101932 cites W1924206262 @default.
• W2887101932 cites W1969976125 @default.
• W2887101932 cites W1973916350 @default.
• W2887101932 cites W1985645498 @default.
• W2887101932 cites W1992070547 @default.
• W2887101932 cites W2000477644 @default.
• W2887101932 cites W2016136864 @default.
• W2887101932 cites W2035679542 @default.
• W2887101932 cites W2037873277 @default.
• W2887101932 cites W2043696829 @default.
• W2887101932 cites W2048733384 @default.
• W2887101932 cites W2056897420 @default.
• W2887101932 cites W2073146203 @default.
• W2887101932 cites W2076161831 @default.
• W2887101932 cites W2084968536 @default.
• W2887101932 cites W2122357705 @default.
• W2887101932 cites W2126091128 @default.
• W2887101932 cites W2137697100 @default.
• W2887101932 cites W2143863753 @default.
• W2887101932 cites W2148174696 @default.
• W2887101932 cites W2158132182 @default.
• W2887101932 cites W2159224316 @default.
• W2887101932 cites W2161821474 @default.
• W2887101932 cites W2292957477 @default.
• W2887101932 cites W2461816685 @default.
• W2887101932 cites W2507541911 @default.
• W2887101932 cites W2560787632 @default.
• W2887101932 cites W2750921047 @default.
• W2887101932 cites W2771032653 @default.
• W2887101932 doi "https://doi.org/10.1111/his.13732" @default.
• W2887101932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30117182" @default.
• W2887101932 hasPublicationYear "2018" @default.
• W2887101932 type Work @default.
• W2887101932 sameAs 2887101932 @default.
• W2887101932 citedByCount "30" @default.
• W2887101932 countsByYear W28871019322019 @default.
• W2887101932 countsByYear W28871019322020 @default.
• W2887101932 countsByYear W28871019322021 @default.
• W2887101932 countsByYear W28871019322022 @default.
• W2887101932 countsByYear W28871019322023 @default.
• W2887101932 crossrefType "journal-article" @default.
• W2887101932 hasAuthorship W2887101932A5011939936 @default.
• W2887101932 hasAuthorship W2887101932A5032578932 @default.
• W2887101932 hasAuthorship W2887101932A5041410809 @default.
• W2887101932 hasAuthorship W2887101932A5060912740 @default.
• W2887101932 hasAuthorship W2887101932A5065196329 @default.
• W2887101932 hasBestOaLocation W28871019321 @default.
• W2887101932 hasConcept C104317684 @default.
• W2887101932 hasConcept C121608353 @default.
• W2887101932 hasConcept C126322002 @default.
• W2887101932 hasConcept C141071460 @default.
• W2887101932 hasConcept C142724271 @default.
• W2887101932 hasConcept C2776350393 @default.
• W2887101932 hasConcept C2776530083 @default.
• W2887101932 hasConcept C2776833033 @default.
• W2887101932 hasConcept C2777546739 @default.
• W2887101932 hasConcept C2779438470 @default.
• W2887101932 hasConcept C2781018059 @default.
• W2887101932 hasConcept C2781187634 @default.
• W2887101932 hasConcept C29537977 @default.
• W2887101932 hasConcept C3018411727 @default.
• W2887101932 hasConcept C501734568 @default.
• W2887101932 hasConcept C502942594 @default.
• W2887101932 hasConcept C526805850 @default.
• W2887101932 hasConcept C55493867 @default.
• W2887101932 hasConcept C71924100 @default.
• W2887101932 hasConcept C86803240 @default.
• W2887101932 hasConceptScore W2887101932C104317684 @default.
• W2887101932 hasConceptScore W2887101932C121608353 @default.
• W2887101932 hasConceptScore W2887101932C126322002 @default.
• W2887101932 hasConceptScore W2887101932C141071460 @default.
• W2887101932 hasConceptScore W2887101932C142724271 @default.
• W2887101932 hasConceptScore W2887101932C2776350393 @default.
• W2887101932 hasConceptScore W2887101932C2776530083 @default.
• W2887101932 hasConceptScore W2887101932C2776833033 @default.
• W2887101932 hasConceptScore W2887101932C2777546739 @default.
• W2887101932 hasConceptScore W2887101932C2779438470 @default.
• W2887101932 hasConceptScore W2887101932C2781018059 @default.
• W2887101932 hasConceptScore W2887101932C2781187634 @default.
• W2887101932 hasConceptScore W2887101932C29537977 @default.
• W2887101932 hasConceptScore W2887101932C3018411727 @default.
• W2887101932 hasConceptScore W2887101932C501734568 @default.
• W2887101932 hasConceptScore W2887101932C502942594 @default.
• W2887101932 hasConceptScore W2887101932C526805850 @default.
• W2887101932 hasConceptScore W2887101932C55493867 @default.
• W2887101932 hasConceptScore W2887101932C71924100 @default.
• W2887101932 hasConceptScore W2887101932C86803240 @default.

• next