FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887119076> ?p ?o ?g. }

• W2887119076 endingPage "1242" @default.
• W2887119076 startingPage "1237" @default.
• W2887119076 abstract "microRNA-22 (miR-22) is a brain-enriched regulatory gene which has been reported to be involved in the development of cancers. The Notch signaling pathway exerts important functions in cell growth. This study is designed to investigate the mechanisms of miR-22-Notch signaling pathway in apoptosis and autophagy of human ovarian cancer cells. After over-expressing miR-22 in human ovarian cancer cell lines OVCAR-3 and SKOV3, cell viability is determined by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) method, cell apoptosis is observed by Flow cytometry (FCM), mRNA expression of miR-22 is measured by RNA preparation and RT-PCR, protein expression of Notch1, Hes1, Beclin1 and LC3B-II is analyzed by Western blot. It is suggested that miR-22 expression is heavily decreased in human ovarian cancer cell lines OVCAR-3 and SKOV3. Over-expression of miR-22 potently suppresses cell viability and authophagy while promotes the percentage of apoptotic cancer cells. In addition, the decreased expression level of Notch1 and its targeted gene is detected in miR-22-over-expressed cells. Moreover, followed by the block of the Notch signaling pathway using Notch1 small interference RNA (siRNA), the effects of miR-22 on the apoptosis and autophagy of human ovarian cancer cell lines OVCAR-3 and SKOV3 are obviously blocked. Together, miR-22 inhibits apoptosis and promotes autophagy of human ovarian cancer cells through the suppression of the Notch signaling pathway, indicating a potential use of miR-22 in the ovarian cancer treatment." @default.
• W2887119076 created "2018-08-22" @default.
• W2887119076 creator A5027423694 @default.
• W2887119076 creator A5043717687 @default.
• W2887119076 creator A5050492878 @default.
• W2887119076 creator A5075031546 @default.
• W2887119076 creator A5086206969 @default.
• W2887119076 date "2018-08-01" @default.
• W2887119076 modified "2023-10-06" @default.
• W2887119076 title "miR-22-Notch Signaling Pathway Is Involved in the Regulation of the Apoptosis and Autophagy in Human Ovarian Cancer Cells" @default.
• W2887119076 cites W1152011753 @default.
• W2887119076 cites W1752520412 @default.
• W2887119076 cites W1977098496 @default.
• W2887119076 cites W1994253118 @default.
• W2887119076 cites W2039069300 @default.
• W2887119076 cites W2052872355 @default.
• W2887119076 cites W2080100819 @default.
• W2887119076 cites W2092059355 @default.
• W2887119076 cites W2113296997 @default.
• W2887119076 cites W2122984076 @default.
• W2887119076 cites W2127463575 @default.
• W2887119076 cites W2152205456 @default.
• W2887119076 cites W2163260588 @default.
• W2887119076 cites W2191798539 @default.
• W2887119076 cites W2229884257 @default.
• W2887119076 cites W2235523093 @default.
• W2887119076 cites W2278976499 @default.
• W2887119076 cites W2289310757 @default.
• W2887119076 cites W2343932903 @default.
• W2887119076 cites W2465674423 @default.
• W2887119076 cites W2515668690 @default.
• W2887119076 cites W2517907818 @default.
• W2887119076 cites W2519927854 @default.
• W2887119076 cites W2540317213 @default.
• W2887119076 cites W2547692803 @default.
• W2887119076 cites W2566478516 @default.
• W2887119076 cites W2583155819 @default.
• W2887119076 cites W2583633591 @default.
• W2887119076 cites W2608501602 @default.
• W2887119076 cites W2731694957 @default.
• W2887119076 cites W289359787 @default.
• W2887119076 cites W834730509 @default.
• W2887119076 doi "https://doi.org/10.1248/bpb.b18-00084" @default.
• W2887119076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30068873" @default.
• W2887119076 hasPublicationYear "2018" @default.
• W2887119076 type Work @default.
• W2887119076 sameAs 2887119076 @default.
• W2887119076 citedByCount "18" @default.
• W2887119076 countsByYear W28871190762019 @default.
• W2887119076 countsByYear W28871190762020 @default.
• W2887119076 countsByYear W28871190762021 @default.
• W2887119076 countsByYear W28871190762022 @default.
• W2887119076 countsByYear W28871190762023 @default.
• W2887119076 crossrefType "journal-article" @default.
• W2887119076 hasAuthorship W2887119076A5027423694 @default.
• W2887119076 hasAuthorship W2887119076A5043717687 @default.
• W2887119076 hasAuthorship W2887119076A5050492878 @default.
• W2887119076 hasAuthorship W2887119076A5075031546 @default.
• W2887119076 hasAuthorship W2887119076A5086206969 @default.
• W2887119076 hasBestOaLocation W28871190761 @default.
• W2887119076 hasConcept C104317684 @default.
• W2887119076 hasConcept C121608353 @default.
• W2887119076 hasConcept C145059251 @default.
• W2887119076 hasConcept C161879069 @default.
• W2887119076 hasConcept C190283241 @default.
• W2887119076 hasConcept C203522944 @default.
• W2887119076 hasConcept C2780283210 @default.
• W2887119076 hasConcept C2780427987 @default.
• W2887119076 hasConcept C2780645649 @default.
• W2887119076 hasConcept C29537977 @default.
• W2887119076 hasConcept C502942594 @default.
• W2887119076 hasConcept C53227056 @default.
• W2887119076 hasConcept C54355233 @default.
• W2887119076 hasConcept C55493867 @default.
• W2887119076 hasConcept C62112901 @default.
• W2887119076 hasConcept C62478195 @default.
• W2887119076 hasConcept C86803240 @default.
• W2887119076 hasConcept C95444343 @default.
• W2887119076 hasConcept C96232424 @default.
• W2887119076 hasConceptScore W2887119076C104317684 @default.
• W2887119076 hasConceptScore W2887119076C121608353 @default.
• W2887119076 hasConceptScore W2887119076C145059251 @default.
• W2887119076 hasConceptScore W2887119076C161879069 @default.
• W2887119076 hasConceptScore W2887119076C190283241 @default.
• W2887119076 hasConceptScore W2887119076C203522944 @default.
• W2887119076 hasConceptScore W2887119076C2780283210 @default.
• W2887119076 hasConceptScore W2887119076C2780427987 @default.
• W2887119076 hasConceptScore W2887119076C2780645649 @default.
• W2887119076 hasConceptScore W2887119076C29537977 @default.
• W2887119076 hasConceptScore W2887119076C502942594 @default.
• W2887119076 hasConceptScore W2887119076C53227056 @default.
• W2887119076 hasConceptScore W2887119076C54355233 @default.
• W2887119076 hasConceptScore W2887119076C55493867 @default.
• W2887119076 hasConceptScore W2887119076C62112901 @default.
• W2887119076 hasConceptScore W2887119076C62478195 @default.
• W2887119076 hasConceptScore W2887119076C86803240 @default.
• W2887119076 hasConceptScore W2887119076C95444343 @default.
• W2887119076 hasConceptScore W2887119076C96232424 @default.

• next