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- W2887196466 abstract "Abstract Acute kidney injury (AKI) is an increasingly encountered complication, affecting up to 60% of patients admitted to an intensive care unit (ICU). Depending on its cause, as many as 17% of patients with AKI may require renal replacement therapy for management of fluid balance, acid-base status, or electrolyte disturbances. Patients with AKI have decreased capacity to excrete fluid and solute. Moreover, they often develop AKI in association with conditions precipitating increased capillary permeability, necessitating aggressive fluid resuscitation, such as sepsis, major trauma, or burn injury. Therefore these patients are at increased risk for fluid accumulation and complications related to fluid overload. Over the last decades, multiple studies have suggested that a positive fluid balance is associated with increased mortality, worsening lung function, and oxygenation and more major surgical complications. Conversely, after initial resuscitation, achieving a neutral or negative fluid balance has been associated with improved gas exchange, greater ventilator-free days, and reduced ICU length of stay. Achieving a negative fluid balance in critically ill patients, in particular in the setting of AKI or reduced kidney function, commonly necessitates use of diuretic therapy. In general, in acute and critical care settings, loop diuretics and thiazide are used most commonly. This chapter reviews the mechanism of actions and clinical use of loop and thiazide diuretics." @default.
- W2887196466 created "2018-08-22" @default.
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- W2887196466 date "2019-01-01" @default.
- W2887196466 modified "2023-10-17" @default.
- W2887196466 title "Loop and Thiazide Diuretics" @default.
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- W2887196466 doi "https://doi.org/10.1016/b978-0-323-44942-7.00061-3" @default.
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