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- W2887204823 endingPage "517.e7" @default.
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- W2887204823 abstract "Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions." @default.
- W2887204823 created "2018-08-22" @default.
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- W2887204823 date "2018-08-01" @default.
- W2887204823 modified "2023-10-16" @default.
- W2887204823 title "Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development" @default.
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- W2887204823 doi "https://doi.org/10.1016/j.devcel.2018.07.005" @default.
- W2887204823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6104814" @default.
- W2887204823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30078729" @default.
- W2887204823 hasPublicationYear "2018" @default.
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