FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887205510> ?p ?o ?g. }

• W2887205510 abstract "[Backgroud and Purpose]: Tumor endothelial cells (TECs) have been reported to have various abnormalities. For example, TECs demonstrate higher expression levels of several molecules (TEC markers) compared with normal endothelial cells (NECs). Recently we identified biglycan (Bgn) as one of TEC markers. Bgn has been reported to be associated with tumor progression in various cancers. In addition, we have found that Bgn secreted by TEC promoted intravasation of tumor cells and lung metastasis in vivo mouse tumors. Lung cancer, of which non-small-cell lung cancer (NSCLC) is the most common form, remains the leading cause of cancer-related mortality worldwide, with many patients presenting with advanced disease at initial diagnosis. Moreover, in spite of recent advances in chemotherapy and targeted therapy, 5-year survival for patients with NSCLC is still disappointingly low at less than 20%. Therefore, it is urgent need to develop effective biomarkers for early diagnosis or new therapeutic target. In this study, we analyzed the association between Bgn expression in TEC in lung cancer and the cancer progression of these patients to evaluate the possibility of Bgn as a biomarker. [Method]: A total 46 patients with lung cancer, who had undergone thoracic surgery at Hokkaido university hospital from February 2015 to March 2017 , were enrolled in this study. First, we performed immunohistochemistry of CD31 and Bgn with serial sections of resected lung tumor tissues, and analyzed the correlation between Bgn positive vessel density in primary lung tumors and clinicopathological factors. Second, we measured the Bgn levels in preoperative serum by ELISA,and the correlation between Bgn positive vessel density in lung tumor tissue and blood Bgn levels. [Result]: The Bgn positive vessel density in primary lung tumor tissue was significantly correlated with primary tumor invasion (p=0.036) and pleural invasion (p=0.036). The preoperative serum Bgn level was also significantly correlated with primary tumor invasion (p=0.0017), pleural invasion (p=0.046) and preoperative blood c-reactive protein level (p=0.012). The Bgn positive vessel density in primary lung tumors was significantly correlated with preoperative serum Bgn level (p Citation Format: Hirofumi Morimoto, Nako Maishi, Yasuhiro Hida, Hiroshi Nishihara, Yutaka Hatanaka, Yoshihiro Matsuno, Toru Nakamura, Satoshi Hirano, Kyoko Hida. Biglycan, tumor endothelial secreting proteoglycan, as possible biomarker for lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2574." @default.
• W2887205510 created "2018-08-22" @default.
• W2887205510 creator A5006667959 @default.
• W2887205510 creator A5025621395 @default.
• W2887205510 creator A5050984306 @default.
• W2887205510 creator A5054053950 @default.
• W2887205510 creator A5060744842 @default.
• W2887205510 creator A5064568192 @default.
• W2887205510 creator A5077400696 @default.
• W2887205510 creator A5084909567 @default.
• W2887205510 creator A5090915905 @default.
• W2887205510 date "2018-07-01" @default.
• W2887205510 modified "2023-09-27" @default.
• W2887205510 title "Abstract 2574: Biglycan, tumor endothelial secreting proteoglycan, as possible biomarker for lung cancer" @default.
• W2887205510 doi "https://doi.org/10.1158/1538-7445.am2018-2574" @default.
• W2887205510 hasPublicationYear "2018" @default.
• W2887205510 type Work @default.
• W2887205510 sameAs 2887205510 @default.
• W2887205510 citedByCount "0" @default.
• W2887205510 crossrefType "proceedings-article" @default.
• W2887205510 hasAuthorship W2887205510A5006667959 @default.
• W2887205510 hasAuthorship W2887205510A5025621395 @default.
• W2887205510 hasAuthorship W2887205510A5050984306 @default.
• W2887205510 hasAuthorship W2887205510A5054053950 @default.
• W2887205510 hasAuthorship W2887205510A5060744842 @default.
• W2887205510 hasAuthorship W2887205510A5064568192 @default.
• W2887205510 hasAuthorship W2887205510A5077400696 @default.
• W2887205510 hasAuthorship W2887205510A5084909567 @default.
• W2887205510 hasAuthorship W2887205510A5090915905 @default.
• W2887205510 hasConcept C105702510 @default.
• W2887205510 hasConcept C121608353 @default.
• W2887205510 hasConcept C126322002 @default.
• W2887205510 hasConcept C142724271 @default.
• W2887205510 hasConcept C143998085 @default.
• W2887205510 hasConcept C204232928 @default.
• W2887205510 hasConcept C2776107976 @default.
• W2887205510 hasConcept C2776256026 @default.
• W2887205510 hasConcept C2778916964 @default.
• W2887205510 hasConcept C2778939058 @default.
• W2887205510 hasConcept C2779013556 @default.
• W2887205510 hasConcept C2779256057 @default.
• W2887205510 hasConcept C2779335624 @default.
• W2887205510 hasConcept C2779794767 @default.
• W2887205510 hasConcept C2780550940 @default.
• W2887205510 hasConcept C2781197716 @default.
• W2887205510 hasConcept C502942594 @default.
• W2887205510 hasConcept C55493867 @default.
• W2887205510 hasConcept C71924100 @default.
• W2887205510 hasConcept C86803240 @default.
• W2887205510 hasConceptScore W2887205510C105702510 @default.
• W2887205510 hasConceptScore W2887205510C121608353 @default.
• W2887205510 hasConceptScore W2887205510C126322002 @default.
• W2887205510 hasConceptScore W2887205510C142724271 @default.
• W2887205510 hasConceptScore W2887205510C143998085 @default.
• W2887205510 hasConceptScore W2887205510C204232928 @default.
• W2887205510 hasConceptScore W2887205510C2776107976 @default.
• W2887205510 hasConceptScore W2887205510C2776256026 @default.
• W2887205510 hasConceptScore W2887205510C2778916964 @default.
• W2887205510 hasConceptScore W2887205510C2778939058 @default.
• W2887205510 hasConceptScore W2887205510C2779013556 @default.
• W2887205510 hasConceptScore W2887205510C2779256057 @default.
• W2887205510 hasConceptScore W2887205510C2779335624 @default.
• W2887205510 hasConceptScore W2887205510C2779794767 @default.
• W2887205510 hasConceptScore W2887205510C2780550940 @default.
• W2887205510 hasConceptScore W2887205510C2781197716 @default.
• W2887205510 hasConceptScore W2887205510C502942594 @default.
• W2887205510 hasConceptScore W2887205510C55493867 @default.
• W2887205510 hasConceptScore W2887205510C71924100 @default.
• W2887205510 hasConceptScore W2887205510C86803240 @default.
• W2887205510 hasLocation W28872055101 @default.
• W2887205510 hasOpenAccess W2887205510 @default.
• W2887205510 hasPrimaryLocation W28872055101 @default.
• W2887205510 hasRelatedWork W1559401050 @default.
• W2887205510 hasRelatedWork W2010580010 @default.
• W2887205510 hasRelatedWork W2017009483 @default.
• W2887205510 hasRelatedWork W2320161565 @default.
• W2887205510 hasRelatedWork W2487824964 @default.
• W2887205510 hasRelatedWork W2554246169 @default.
• W2887205510 hasRelatedWork W2953501696 @default.
• W2887205510 hasRelatedWork W2972702314 @default.
• W2887205510 hasRelatedWork W3208122506 @default.
• W2887205510 hasRelatedWork W3213125396 @default.
• W2887205510 isParatext "false" @default.
• W2887205510 isRetracted "false" @default.
• W2887205510 magId "2887205510" @default.
• W2887205510 workType "article" @default.