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- W2887207624 abstract "Abstract The present study investigated the interactions of sodium deoxycholate (SDC) and chlorpheniramine maleate (CPM) in aqueous solution to help develop alternative pharmaceutical formulations. Surface tension measurements were used to characterize mixed aggregate formation of CPM‐SDC. The mixed system showed a large turbid region between α CPM = 0.3 and 0.9. The theoretical approaches of Clint, Rubingh, and Rosen were used to determine the nature of the interactions between CPM and SDC in the bulk as well as at the interface. Negative interaction parameter (− β m ) values indicated strong attractive interactions between CPM and SDC mixed solution. The Δ G o ex values for all CPM‐SDC systems were found to be negative and energetically favorable for micellization as well as adsorption processes. The dynamic light scattering results have demonstrated the size ( d H ) of CPM‐SDC aggregates in the composition from α CPM = 0.0 to 1.0. In the middle composition α CPM = 0.5, very large‐sized aggregates were formed." @default.
- W2887207624 created "2018-08-22" @default.
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- W2887207624 creator A5012848567 @default.
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- W2887207624 date "2018-08-13" @default.
- W2887207624 modified "2023-10-17" @default.
- W2887207624 title "Physicochemical Interactions of Chlorpheniramine Maleate with Sodium Deoxycholate in Aqueous Solution" @default.
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- W2887207624 doi "https://doi.org/10.1002/jsde.12186" @default.
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