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- W2887228013 abstract "Objective: To compare subthalamic nucleus (STN) deep brain stimulation (DBS) with globus pallidus interna (GPi) DBS for tremor suppression in Parkinson’s disease (PD). Background: DBS is an effective surgical therapy that has been shown to provide significant benefit for motor symptoms in PD. Currently, two main structures targeted to treat motor complications in PD are the GPi and STN. Although some groups traditionally favor STN over GPi for tremor suppression, evidence demonstrating superiority in long term tremor control is limited. Design/Methods: For this systematic review and meta-analysis, we searched MEDLINE for all randomized trials comparing STN vs GPi DBS in PD that were published before March 2017. We excluded studies with fewer than 10 patients in each study arm. Five studies were examined in a random effects model meta-analysis. We then conducted moderator variable analysis on the stimulation target to determine if there was a treatment effect difference for STN versus GPi. Results: We compared DBS ON versus OFF and found a significant overall standardized difference mean effect: Effect Size = 0.36; 95% CI = 0.316 – 0.395; P Conclusions: DBS is effective in reducing tremor in PD patients regardless of stimulation target. There was no significant difference in the degree of tremor suppression in STN DBS versus GPi DBS. Disclosure: Dr. Wong has nothing to disclose. Dr. Cauraugh has nothing to disclose. Dr. Ho has nothing to disclose. Dr. Broderick has nothing to disclose. Dr. Ramirez Zamora has nothing to disclose. Dr. Almeida has nothing to disclose. Dr Wagle-Shukla has nothing to disclose. Dr. Wilson has nothing to disclose. Dr. De Bie has nothing to disclose. Dr. Weaver has nothing to disclose. Dr. Okun has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with National Parkinson Foundation, Medscape, Mededicus." @default.
- W2887228013 created "2018-08-22" @default.
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- W2887228013 date "2018-04-10" @default.
- W2887228013 modified "2023-09-28" @default.
- W2887228013 title "STN vs. GPi deep brain stimulation for tremor suppression in Parkinson’s disease: A systematic review and meta-analysis (P4.057)" @default.
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