FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887241590> ?p ?o ?g. }

• W2887241590 endingPage "504" @default.
• W2887241590 startingPage "497" @default.
• W2887241590 abstract "Huntington's disease (HD) is a monogenic, fully penetrant neurodegenerative disorder, providing an ideal model for understanding brain changes occurring in the years prior to disease onset. Diffusion tensor imaging (DTI) studies show widespread white matter disorganization in the early premanifest stages (pre-HD). However, although DTI has proved informative, it provides only limited information about underlying changes in tissue properties. Neurite orientation dispersion and density imaging (NODDI) is a novel magnetic resonance imaging (MRI) technique for characterizing axonal pathology more specifically, providing metrics that separately quantify axonal density and axonal organization. Here, we provide the first in vivo characterization of white matter pathology in pre-HD using NODDI.Diffusion-weighted MRI data that support DTI and NODDI were acquired from 38 pre-HD and 45 control participants. Using whole-brain and region-of-interest analyses, NODDI metrics were compared between groups and correlated with clinical scores of disease progression. Whole-brain changes in DTI metrics were also examined.The pre-HD group displayed widespread reductions in axonal density compared with control participants; this correlated with measures of clinical disease progression in the body and genu of the corpus callosum. There was also evidence in the pre-HD group of increased coherence of axonal packing in the white matter surrounding the basal ganglia.Our findings suggest that reduced axonal density is one of the major factors underlying white matter pathology in pre-HD, coupled with altered local organization in areas surrounding the basal ganglia. NODDI metrics show promise in providing more specific information about the biological processes underlying HD and neurodegeneration per se. Ann Neurol 2018;84:497-504." @default.
• W2887241590 created "2018-08-22" @default.
• W2887241590 creator A5003759585 @default.
• W2887241590 creator A5004911280 @default.
• W2887241590 creator A5019533089 @default.
• W2887241590 creator A5022852256 @default.
• W2887241590 creator A5026091604 @default.
• W2887241590 creator A5027293126 @default.
• W2887241590 creator A5029597969 @default.
• W2887241590 creator A5041885603 @default.
• W2887241590 creator A5074881456 @default.
• W2887241590 creator A5083265775 @default.
• W2887241590 date "2018-09-15" @default.
• W2887241590 modified "2023-10-17" @default.
• W2887241590 title "In vivo characterization of white matter pathology in premanifest huntington's disease" @default.
• W2887241590 cites W1179800764 @default.
• W2887241590 cites W1526085390 @default.
• W2887241590 cites W1556842271 @default.
• W2887241590 cites W1964802316 @default.
• W2887241590 cites W1973909957 @default.
• W2887241590 cites W1981466739 @default.
• W2887241590 cites W1982689204 @default.
• W2887241590 cites W1989339023 @default.
• W2887241590 cites W1998316883 @default.
• W2887241590 cites W2032120877 @default.
• W2887241590 cites W2032254014 @default.
• W2887241590 cites W2046557060 @default.
• W2887241590 cites W204697952 @default.
• W2887241590 cites W2050781164 @default.
• W2887241590 cites W2078320135 @default.
• W2887241590 cites W2095099413 @default.
• W2887241590 cites W2113441901 @default.
• W2887241590 cites W2118546680 @default.
• W2887241590 cites W2148828979 @default.
• W2887241590 cites W2150667092 @default.
• W2887241590 cites W2150852495 @default.
• W2887241590 cites W2163671213 @default.
• W2887241590 cites W2234216169 @default.
• W2887241590 cites W2283761130 @default.
• W2887241590 cites W2602965723 @default.
• W2887241590 cites W2604707458 @default.
• W2887241590 cites W2605884509 @default.
• W2887241590 cites W2977883299 @default.
• W2887241590 cites W4235770099 @default.
• W2887241590 doi "https://doi.org/10.1002/ana.25309" @default.
• W2887241590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6221120" @default.
• W2887241590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30063250" @default.
• W2887241590 hasPublicationYear "2018" @default.
• W2887241590 type Work @default.
• W2887241590 sameAs 2887241590 @default.
• W2887241590 citedByCount "49" @default.
• W2887241590 countsByYear W28872415902018 @default.
• W2887241590 countsByYear W28872415902019 @default.
• W2887241590 countsByYear W28872415902020 @default.
• W2887241590 countsByYear W28872415902021 @default.
• W2887241590 countsByYear W28872415902022 @default.
• W2887241590 countsByYear W28872415902023 @default.
• W2887241590 crossrefType "journal-article" @default.
• W2887241590 hasAuthorship W2887241590A5003759585 @default.
• W2887241590 hasAuthorship W2887241590A5004911280 @default.
• W2887241590 hasAuthorship W2887241590A5019533089 @default.
• W2887241590 hasAuthorship W2887241590A5022852256 @default.
• W2887241590 hasAuthorship W2887241590A5026091604 @default.
• W2887241590 hasAuthorship W2887241590A5027293126 @default.
• W2887241590 hasAuthorship W2887241590A5029597969 @default.
• W2887241590 hasAuthorship W2887241590A5041885603 @default.
• W2887241590 hasAuthorship W2887241590A5074881456 @default.
• W2887241590 hasAuthorship W2887241590A5083265775 @default.
• W2887241590 hasBestOaLocation W28872415901 @default.
• W2887241590 hasConcept C126838900 @default.
• W2887241590 hasConcept C142724271 @default.
• W2887241590 hasConcept C143409427 @default.
• W2887241590 hasConcept C149550507 @default.
• W2887241590 hasConcept C15744967 @default.
• W2887241590 hasConcept C169760540 @default.
• W2887241590 hasConcept C2778183499 @default.
• W2887241590 hasConcept C2778187257 @default.
• W2887241590 hasConcept C2779134260 @default.
• W2887241590 hasConcept C2780647506 @default.
• W2887241590 hasConcept C2781192897 @default.
• W2887241590 hasConcept C529278444 @default.
• W2887241590 hasConcept C71924100 @default.
• W2887241590 hasConceptScore W2887241590C126838900 @default.
• W2887241590 hasConceptScore W2887241590C142724271 @default.
• W2887241590 hasConceptScore W2887241590C143409427 @default.
• W2887241590 hasConceptScore W2887241590C149550507 @default.
• W2887241590 hasConceptScore W2887241590C15744967 @default.
• W2887241590 hasConceptScore W2887241590C169760540 @default.
• W2887241590 hasConceptScore W2887241590C2778183499 @default.
• W2887241590 hasConceptScore W2887241590C2778187257 @default.
• W2887241590 hasConceptScore W2887241590C2779134260 @default.
• W2887241590 hasConceptScore W2887241590C2780647506 @default.
• W2887241590 hasConceptScore W2887241590C2781192897 @default.
• W2887241590 hasConceptScore W2887241590C529278444 @default.
• W2887241590 hasConceptScore W2887241590C71924100 @default.
• W2887241590 hasFunder F4320308687 @default.
• W2887241590 hasFunder F4320311904 @default.
• W2887241590 hasFunder F4320322725 @default.

• next